Functional recovery after implantation of artificial nerve grafts in the rat- a systematic review

PURPOSE: The aim of this study was to compare functional data of different nerve-gap bridging materials evaluated in rat experiments by means of a systematic review. MATERIALS AND METHODS: A systematic review was conducted, searching MEDLINE, HTS and CENTRAL to identify all trials evaluating functio...

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Detalles Bibliográficos
Autores principales: Sinis, Nektarios, Kraus, Armin, Tselis, Nikolaos, Haerle, Max, Werdin, Frank, Schaller, Hans-Eberhard
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770034/
https://www.ncbi.nlm.nih.gov/pubmed/19852862
http://dx.doi.org/10.1186/1749-7221-4-19
Descripción
Sumario:PURPOSE: The aim of this study was to compare functional data of different nerve-gap bridging materials evaluated in rat experiments by means of a systematic review. MATERIALS AND METHODS: A systematic review was conducted, searching MEDLINE, HTS and CENTRAL to identify all trials evaluating functional recovery of artificial nerve conduits in the rat model. RESULTS: There was a trend towards a favourable outcome of conduits coated with Schwann-cells compared to the plain synthetics. Histomorphometry, electrophysiology and muscle-weight correlated poorly with functional outcome. CONCLUSION: Schwann-cell coated conduits showed promising results concerning functional recovery. Further standardization in outcome reporting is encouraged.

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