Functional recovery after implantation of artificial nerve grafts in the rat- a systematic review

PURPOSE: The aim of this study was to compare functional data of different nerve-gap bridging materials evaluated in rat experiments by means of a systematic review. MATERIALS AND METHODS: A systematic review was conducted, searching MEDLINE, HTS and CENTRAL to identify all trials evaluating functio...

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Autores principales: Sinis, Nektarios, Kraus, Armin, Tselis, Nikolaos, Haerle, Max, Werdin, Frank, Schaller, Hans-Eberhard
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770034/
https://www.ncbi.nlm.nih.gov/pubmed/19852862
http://dx.doi.org/10.1186/1749-7221-4-19
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author Sinis, Nektarios
Kraus, Armin
Tselis, Nikolaos
Haerle, Max
Werdin, Frank
Schaller, Hans-Eberhard
author_facet Sinis, Nektarios
Kraus, Armin
Tselis, Nikolaos
Haerle, Max
Werdin, Frank
Schaller, Hans-Eberhard
author_sort Sinis, Nektarios
collection PubMed
description PURPOSE: The aim of this study was to compare functional data of different nerve-gap bridging materials evaluated in rat experiments by means of a systematic review. MATERIALS AND METHODS: A systematic review was conducted, searching MEDLINE, HTS and CENTRAL to identify all trials evaluating functional recovery of artificial nerve conduits in the rat model. RESULTS: There was a trend towards a favourable outcome of conduits coated with Schwann-cells compared to the plain synthetics. Histomorphometry, electrophysiology and muscle-weight correlated poorly with functional outcome. CONCLUSION: Schwann-cell coated conduits showed promising results concerning functional recovery. Further standardization in outcome reporting is encouraged.
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spelling pubmed-27700342009-10-29 Functional recovery after implantation of artificial nerve grafts in the rat- a systematic review Sinis, Nektarios Kraus, Armin Tselis, Nikolaos Haerle, Max Werdin, Frank Schaller, Hans-Eberhard J Brachial Plex Peripher Nerve Inj Review PURPOSE: The aim of this study was to compare functional data of different nerve-gap bridging materials evaluated in rat experiments by means of a systematic review. MATERIALS AND METHODS: A systematic review was conducted, searching MEDLINE, HTS and CENTRAL to identify all trials evaluating functional recovery of artificial nerve conduits in the rat model. RESULTS: There was a trend towards a favourable outcome of conduits coated with Schwann-cells compared to the plain synthetics. Histomorphometry, electrophysiology and muscle-weight correlated poorly with functional outcome. CONCLUSION: Schwann-cell coated conduits showed promising results concerning functional recovery. Further standardization in outcome reporting is encouraged. BioMed Central 2009-10-25 /pmc/articles/PMC2770034/ /pubmed/19852862 http://dx.doi.org/10.1186/1749-7221-4-19 Text en Copyright © 2009 Sinis et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Sinis, Nektarios
Kraus, Armin
Tselis, Nikolaos
Haerle, Max
Werdin, Frank
Schaller, Hans-Eberhard
Functional recovery after implantation of artificial nerve grafts in the rat- a systematic review
title Functional recovery after implantation of artificial nerve grafts in the rat- a systematic review
title_full Functional recovery after implantation of artificial nerve grafts in the rat- a systematic review
title_fullStr Functional recovery after implantation of artificial nerve grafts in the rat- a systematic review
title_full_unstemmed Functional recovery after implantation of artificial nerve grafts in the rat- a systematic review
title_short Functional recovery after implantation of artificial nerve grafts in the rat- a systematic review
title_sort functional recovery after implantation of artificial nerve grafts in the rat- a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770034/
https://www.ncbi.nlm.nih.gov/pubmed/19852862
http://dx.doi.org/10.1186/1749-7221-4-19
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