The nuclear envelopathies and human diseases

The nuclear envelope (NE) consists of two membrane layers that segregate the nuclear from the cytoplasmic contents. Recent progress in our understanding of nuclear-lamina associated diseases has revealed intriguing connections between the envelope components and nuclear processes. Here, we review th...

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Detalles Bibliográficos
Autores principales: Chi, Ya-Hui, Chen, Zi-Jie, Jeang, Kuan-Teh
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770040/
https://www.ncbi.nlm.nih.gov/pubmed/19849840
http://dx.doi.org/10.1186/1423-0127-16-96
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author Chi, Ya-Hui
Chen, Zi-Jie
Jeang, Kuan-Teh
author_facet Chi, Ya-Hui
Chen, Zi-Jie
Jeang, Kuan-Teh
author_sort Chi, Ya-Hui
collection PubMed
description The nuclear envelope (NE) consists of two membrane layers that segregate the nuclear from the cytoplasmic contents. Recent progress in our understanding of nuclear-lamina associated diseases has revealed intriguing connections between the envelope components and nuclear processes. Here, we review the functions of the nuclear envelope in chromosome organization, gene expression, DNA repair and cell cycle progression, and correlate deficiencies in envelope function with human pathologies.
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spelling pubmed-27700402009-10-29 The nuclear envelopathies and human diseases Chi, Ya-Hui Chen, Zi-Jie Jeang, Kuan-Teh J Biomed Sci Review The nuclear envelope (NE) consists of two membrane layers that segregate the nuclear from the cytoplasmic contents. Recent progress in our understanding of nuclear-lamina associated diseases has revealed intriguing connections between the envelope components and nuclear processes. Here, we review the functions of the nuclear envelope in chromosome organization, gene expression, DNA repair and cell cycle progression, and correlate deficiencies in envelope function with human pathologies. BioMed Central 2009-10-22 /pmc/articles/PMC2770040/ /pubmed/19849840 http://dx.doi.org/10.1186/1423-0127-16-96 Text en Copyright ©2009 Chi et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Chi, Ya-Hui
Chen, Zi-Jie
Jeang, Kuan-Teh
The nuclear envelopathies and human diseases
title The nuclear envelopathies and human diseases
title_full The nuclear envelopathies and human diseases
title_fullStr The nuclear envelopathies and human diseases
title_full_unstemmed The nuclear envelopathies and human diseases
title_short The nuclear envelopathies and human diseases
title_sort nuclear envelopathies and human diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770040/
https://www.ncbi.nlm.nih.gov/pubmed/19849840
http://dx.doi.org/10.1186/1423-0127-16-96
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