CD4(+) T Cell-Derived IL-2 Signals during Early Priming Advances Primary CD8(+) T Cell Responses

Stimulating naïve CD8(+) T cells with specific antigens and costimulatory signals is insufficient to induce optimal clonal expansion and effector functions. In this study, we show that the activation and differentiation of CD8(+) T cells require IL-2 provided by activated CD4(+) T cells at the initi...

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Detalles Bibliográficos
Autores principales: Lai, Yo-Ping, Lin, Chia-Ching, Liao, Wan-Jung, Tang, Chih-Yung, Chen, Shu-Ching
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770320/
https://www.ncbi.nlm.nih.gov/pubmed/19901991
http://dx.doi.org/10.1371/journal.pone.0007766

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