Insight to pyrazinamide resistance inMycobacterium tuberculosisby molecular docking

Pyrazinamide (PZA) - an important drug in the anti-tuberculosis therapy, activated by an enzyme Pyrazinamidase (PZase). The basis of PZA resistance in Mycobacterium tuberculosis was owing to mutation in pncA gene coding for PZase. Homology modeling of PZase was performed using software Discovery Stu...

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Detalles Bibliográficos
Autores principales: Unissa, Amirudeen Nusrath, Selvakumar, Nagamiah, Hassan, Sameer
Formato: Texto
Lenguaje:English
Publicado: Biomedical Informatics 2009
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770367/
https://www.ncbi.nlm.nih.gov/pubmed/20011149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770367/
https://www.ncbi.nlm.nih.gov/pubmed/20011149

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