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Kinetics of deamination and Cu(II)/H(2)O(2)/Ascorbate-induced formation of 5-methylcytosine glycol at CpG sites in duplex DNA
Mutation in p53 tumor suppressor gene is a hallmark of human cancers. Six major mutational hotspots in p53 contain methylated CpG (mCpG) sites, and C →T transition is the most common mutation at these sites. It was hypothesized that the formation of 5-methylcytosine glycol induced by reactive oxygen...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770644/ https://www.ncbi.nlm.nih.gov/pubmed/19706732 http://dx.doi.org/10.1093/nar/gkp615 |