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Human Pif1 helicase unwinds synthetic DNA structures resembling stalled DNA replication forks

Pif-1 proteins are 5′→3′ superfamily 1 (SF1) helicases that in yeast have roles in the maintenance of mitochondrial and nuclear genome stability. The functions and activities of the human enzyme (hPif1) are unclear, but here we describe its DNA binding and DNA remodeling activities. We demonstrate t...

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Detalles Bibliográficos
Autores principales:	George, Tresa, Wen, Qin, Griffiths, Richard, Ganesh, Anil, Meuth, Mark, Sanders, Cyril M.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770657/ https://www.ncbi.nlm.nih.gov/pubmed/19700773 http://dx.doi.org/10.1093/nar/gkp671

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