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Targeted gene conversion induced by triplex-directed psoralen interstrand crosslinks in mammalian cells
Correction of a defective gene is a promising approach for both basic research and clinical gene therapy. However, the absence of site-specific targeting and the low efficiency of homologous recombination in human cells present barriers to successful gene targeting. In an effort to overcome these ba...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770658/ https://www.ncbi.nlm.nih.gov/pubmed/19726585 http://dx.doi.org/10.1093/nar/gkp678 |