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The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer
BACKGROUND: Both TGF-β1 and VEGF play a critic role in the multiple-step process of tumorgenesis of gastric cancer. Single nucleotide polymorphisms (SNPs) of the TGFB1 and VEGF genes have been associated with risk and progression of many cancers. In this study, we investigated the association betwee...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771032/ https://www.ncbi.nlm.nih.gov/pubmed/19835575 http://dx.doi.org/10.1186/1471-230X-9-77 |
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author | Guan, Xiaoxiang Zhao, Hui Niu, Jiangong Tang, Dongfeng Ajani, Jaffer A Wei, Qingyi |
author_facet | Guan, Xiaoxiang Zhao, Hui Niu, Jiangong Tang, Dongfeng Ajani, Jaffer A Wei, Qingyi |
author_sort | Guan, Xiaoxiang |
collection | PubMed |
description | BACKGROUND: Both TGF-β1 and VEGF play a critic role in the multiple-step process of tumorgenesis of gastric cancer. Single nucleotide polymorphisms (SNPs) of the TGFB1 and VEGF genes have been associated with risk and progression of many cancers. In this study, we investigated the association between potentially functional SNPs of these two genes and risk of gastric cancer in a US population. METHODS: The risk associated with genotypes and haplotypes of four TGFB1 SNPs and four VEGF SNPs were determined by multivariate logistic regression analysis in 171 patients with gastric cancer and 353 cancer-free controls frequency-matched by age, sex and ethnicity. RESULTS: Compared with the VEGF-634GG genotype, the -634CG genotype and the combined -634CG+CC genotypes were associated with a significantly elevated risk of gastric cancer (adjusted OR = 1.88, 95% CI = 1.24-2.86 and adjusted OR = 1.56, 95% CI = 1.07-2.27, respectively). However, none of other TGFB1 and VEGF SNPs was associated with risk of gastric cancer. CONCLUSION: Our data suggested that the VEGF-634G>C SNP may be a marker for susceptibility to gastric cancer, and this finding needs to be validated in larger studies. |
format | Text |
id | pubmed-2771032 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-27710322009-10-31 The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer Guan, Xiaoxiang Zhao, Hui Niu, Jiangong Tang, Dongfeng Ajani, Jaffer A Wei, Qingyi BMC Gastroenterol Research Article BACKGROUND: Both TGF-β1 and VEGF play a critic role in the multiple-step process of tumorgenesis of gastric cancer. Single nucleotide polymorphisms (SNPs) of the TGFB1 and VEGF genes have been associated with risk and progression of many cancers. In this study, we investigated the association between potentially functional SNPs of these two genes and risk of gastric cancer in a US population. METHODS: The risk associated with genotypes and haplotypes of four TGFB1 SNPs and four VEGF SNPs were determined by multivariate logistic regression analysis in 171 patients with gastric cancer and 353 cancer-free controls frequency-matched by age, sex and ethnicity. RESULTS: Compared with the VEGF-634GG genotype, the -634CG genotype and the combined -634CG+CC genotypes were associated with a significantly elevated risk of gastric cancer (adjusted OR = 1.88, 95% CI = 1.24-2.86 and adjusted OR = 1.56, 95% CI = 1.07-2.27, respectively). However, none of other TGFB1 and VEGF SNPs was associated with risk of gastric cancer. CONCLUSION: Our data suggested that the VEGF-634G>C SNP may be a marker for susceptibility to gastric cancer, and this finding needs to be validated in larger studies. BioMed Central 2009-10-16 /pmc/articles/PMC2771032/ /pubmed/19835575 http://dx.doi.org/10.1186/1471-230X-9-77 Text en Copyright ©2009 Guan et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Guan, Xiaoxiang Zhao, Hui Niu, Jiangong Tang, Dongfeng Ajani, Jaffer A Wei, Qingyi The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer |
title | The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer |
title_full | The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer |
title_fullStr | The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer |
title_full_unstemmed | The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer |
title_short | The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer |
title_sort | vegf -634g>c promoter polymorphism is associated with risk of gastric cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771032/ https://www.ncbi.nlm.nih.gov/pubmed/19835575 http://dx.doi.org/10.1186/1471-230X-9-77 |
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