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Murine Pancreatic Beta TC3 Cells Show Greater 2′, 5′-Oligoadenylate Synthetase (2′5′AS) Antiviral Enzyme Activity and Apoptosis Following IFN-α or Poly(I:C) Treatment than Pancreatic Alpha TC3 Cells

Type 1 diabetes is caused by autoimmune destruction of pancreatic beta cells, possibly virus initiated. Virus infection induces alpha-interferon (IFN-α), leading to upregulation of genes encoding double-stranded (ds) RNA-dependent antiviral enzymes 2′, 5′-oligoadenylate synthetase (2′5′AS) and PKR (...

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Detalles Bibliográficos
Autores principales:	Li, M., Zheng, D. -J., Field, L. L., Bonnevie-Nielsen, V.
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771153/ https://www.ncbi.nlm.nih.gov/pubmed/19888425 http://dx.doi.org/10.1155/2009/631026

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