Transarterial Chemoembolization of Metastatic Colorectal Carcinoma with Drug-Eluting Beads, Irinotecan (DEBIRI): Multi-Institutional Registry

The purpose of this study was to evaluate the patient tolerance and efficacy of delivering locoregional chemotherapy to metastatic colorectal (MC) hepatic metastases via hepatic trans-arterial approach using irinotecan loaded drug eluting beads. This open-label, multi-center, single arm study includ...

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Autores principales: Martin, Robert C. G., Joshi, Jonathan, Robbins, Ken, Tomalty, Dana, O'Hara, Ryan, Tatum, Cliff
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771155/
https://www.ncbi.nlm.nih.gov/pubmed/19888427
http://dx.doi.org/10.1155/2009/539795
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author Martin, Robert C. G.
Joshi, Jonathan
Robbins, Ken
Tomalty, Dana
O'Hara, Ryan
Tatum, Cliff
author_facet Martin, Robert C. G.
Joshi, Jonathan
Robbins, Ken
Tomalty, Dana
O'Hara, Ryan
Tatum, Cliff
author_sort Martin, Robert C. G.
collection PubMed
description The purpose of this study was to evaluate the patient tolerance and efficacy of delivering locoregional chemotherapy to metastatic colorectal (MC) hepatic metastases via hepatic trans-arterial approach using irinotecan loaded drug eluting beads. This open-label, multi-center, single arm study included 30 MC patients, who had failed first line therapy. Of the 57 total embolization sessions, 12 (21% of sessions) were associated with adverse reactions during or after the treatment. After a median followup of 9 months, response rates by modified RECIST were 75% at 3 months and 66% at 6 months. Hepatic trans-arterial therapy using Irinotecan loaded DC Bead(TM) was safe and effective in the treatment of MCC as demonstrated by a minimal complication rate and acceptable tumor response.
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spelling pubmed-27711552009-11-03 Transarterial Chemoembolization of Metastatic Colorectal Carcinoma with Drug-Eluting Beads, Irinotecan (DEBIRI): Multi-Institutional Registry Martin, Robert C. G. Joshi, Jonathan Robbins, Ken Tomalty, Dana O'Hara, Ryan Tatum, Cliff J Oncol Clinical Study The purpose of this study was to evaluate the patient tolerance and efficacy of delivering locoregional chemotherapy to metastatic colorectal (MC) hepatic metastases via hepatic trans-arterial approach using irinotecan loaded drug eluting beads. This open-label, multi-center, single arm study included 30 MC patients, who had failed first line therapy. Of the 57 total embolization sessions, 12 (21% of sessions) were associated with adverse reactions during or after the treatment. After a median followup of 9 months, response rates by modified RECIST were 75% at 3 months and 66% at 6 months. Hepatic trans-arterial therapy using Irinotecan loaded DC Bead(TM) was safe and effective in the treatment of MCC as demonstrated by a minimal complication rate and acceptable tumor response. Hindawi Publishing Corporation 2009 2009-10-29 /pmc/articles/PMC2771155/ /pubmed/19888427 http://dx.doi.org/10.1155/2009/539795 Text en Copyright © 2009 Robert C. G. Martin et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Martin, Robert C. G.
Joshi, Jonathan
Robbins, Ken
Tomalty, Dana
O'Hara, Ryan
Tatum, Cliff
Transarterial Chemoembolization of Metastatic Colorectal Carcinoma with Drug-Eluting Beads, Irinotecan (DEBIRI): Multi-Institutional Registry
title Transarterial Chemoembolization of Metastatic Colorectal Carcinoma with Drug-Eluting Beads, Irinotecan (DEBIRI): Multi-Institutional Registry
title_full Transarterial Chemoembolization of Metastatic Colorectal Carcinoma with Drug-Eluting Beads, Irinotecan (DEBIRI): Multi-Institutional Registry
title_fullStr Transarterial Chemoembolization of Metastatic Colorectal Carcinoma with Drug-Eluting Beads, Irinotecan (DEBIRI): Multi-Institutional Registry
title_full_unstemmed Transarterial Chemoembolization of Metastatic Colorectal Carcinoma with Drug-Eluting Beads, Irinotecan (DEBIRI): Multi-Institutional Registry
title_short Transarterial Chemoembolization of Metastatic Colorectal Carcinoma with Drug-Eluting Beads, Irinotecan (DEBIRI): Multi-Institutional Registry
title_sort transarterial chemoembolization of metastatic colorectal carcinoma with drug-eluting beads, irinotecan (debiri): multi-institutional registry
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771155/
https://www.ncbi.nlm.nih.gov/pubmed/19888427
http://dx.doi.org/10.1155/2009/539795
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