CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation

Location of embryonic lymph node development is determined by the initial clustering of lymphoid tissue inducer cells. We demonstrate that both CXCL13 and CCL21 attracted E12.5–E14.5 lymphoid tissue inducer cells and that initial clustering exclusively depended on CXCL13. Retinoic acid induced early...

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Autores principales: van de Pavert, Serge A., Olivier, Brenda J., Goverse, Gera, Vondenhoff, Mark F., Greuter, Mascha, Beke, Patrick, Kusser, Kim, Höpken, Uta E., Lipp, Martin, Niederreither, Karen, Blomhoff, Rune, Sitnik, Kasia, Agace, William W., Randall, Troy D., de Jonge, Wouter J., Mebius, Reina E.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771164/
https://www.ncbi.nlm.nih.gov/pubmed/19783990
http://dx.doi.org/10.1038/ni.1789
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author van de Pavert, Serge A.
Olivier, Brenda J.
Goverse, Gera
Vondenhoff, Mark F.
Greuter, Mascha
Beke, Patrick
Kusser, Kim
Höpken, Uta E.
Lipp, Martin
Niederreither, Karen
Blomhoff, Rune
Sitnik, Kasia
Agace, William W.
Randall, Troy D.
de Jonge, Wouter J.
Mebius, Reina E.
author_facet van de Pavert, Serge A.
Olivier, Brenda J.
Goverse, Gera
Vondenhoff, Mark F.
Greuter, Mascha
Beke, Patrick
Kusser, Kim
Höpken, Uta E.
Lipp, Martin
Niederreither, Karen
Blomhoff, Rune
Sitnik, Kasia
Agace, William W.
Randall, Troy D.
de Jonge, Wouter J.
Mebius, Reina E.
author_sort van de Pavert, Serge A.
collection PubMed
description Location of embryonic lymph node development is determined by the initial clustering of lymphoid tissue inducer cells. We demonstrate that both CXCL13 and CCL21 attracted E12.5–E14.5 lymphoid tissue inducer cells and that initial clustering exclusively depended on CXCL13. Retinoic acid induced early CXCL13 expression in stromal organizer cells independent of lymphotoxin signaling. Notably, neurons adjacent to the lymph node anlagen expressed enzymes essential for retinoic acid synthesis. Furthermore, stimulation of parasymphathetic neural output in adults led to a retinoic acid receptor-dependent induction of CXCL13 in the gut. Therefore, our data show that initiation of lymph node development is controlled by retinoic acid-mediated expression of CXCL13 and suggest that retinoic acid may be provided by adjacent neurons.
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spelling pubmed-27711642010-05-01 CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation van de Pavert, Serge A. Olivier, Brenda J. Goverse, Gera Vondenhoff, Mark F. Greuter, Mascha Beke, Patrick Kusser, Kim Höpken, Uta E. Lipp, Martin Niederreither, Karen Blomhoff, Rune Sitnik, Kasia Agace, William W. Randall, Troy D. de Jonge, Wouter J. Mebius, Reina E. Nat Immunol Article Location of embryonic lymph node development is determined by the initial clustering of lymphoid tissue inducer cells. We demonstrate that both CXCL13 and CCL21 attracted E12.5–E14.5 lymphoid tissue inducer cells and that initial clustering exclusively depended on CXCL13. Retinoic acid induced early CXCL13 expression in stromal organizer cells independent of lymphotoxin signaling. Notably, neurons adjacent to the lymph node anlagen expressed enzymes essential for retinoic acid synthesis. Furthermore, stimulation of parasymphathetic neural output in adults led to a retinoic acid receptor-dependent induction of CXCL13 in the gut. Therefore, our data show that initiation of lymph node development is controlled by retinoic acid-mediated expression of CXCL13 and suggest that retinoic acid may be provided by adjacent neurons. 2009-09-27 2009-11 /pmc/articles/PMC2771164/ /pubmed/19783990 http://dx.doi.org/10.1038/ni.1789 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
van de Pavert, Serge A.
Olivier, Brenda J.
Goverse, Gera
Vondenhoff, Mark F.
Greuter, Mascha
Beke, Patrick
Kusser, Kim
Höpken, Uta E.
Lipp, Martin
Niederreither, Karen
Blomhoff, Rune
Sitnik, Kasia
Agace, William W.
Randall, Troy D.
de Jonge, Wouter J.
Mebius, Reina E.
CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation
title CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation
title_full CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation
title_fullStr CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation
title_full_unstemmed CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation
title_short CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation
title_sort cxcl13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771164/
https://www.ncbi.nlm.nih.gov/pubmed/19783990
http://dx.doi.org/10.1038/ni.1789
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