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Changes on the Physiological Lactonase Activity of Serum Paraoxonase 1 by a Diet Intervention for Weight Loss in Healthy Overweight and Obese Women
Low caloric diet (LCD) is used for weight loss. Paraoxonase 1 (PON-1) is associated with the antioxidant functions of high-density lipoprotein (HDL). Among limited data on the relationships between obesity and PON-1, there has been no study on the effects of a stand-alone LCD on the physiological la...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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the Society for Free Radical Research Japan
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771255/ https://www.ncbi.nlm.nih.gov/pubmed/19902024 http://dx.doi.org/10.3164/jcbn.09-26 |
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author | Kotani, Kazuhiko Sakane, Naoki Sano, Yoshiko Tsuzaki, Kokoro Matsuoka, Yukiyo Egawa, Kahori Yoshimura, Makiko Horikawa, Chika Kitagawa, Yoshinori Kiso, Yoshinobu Kimura, Satoshi Schulze, John Taing, Jennifer Gugliucci, Alejandro |
author_facet | Kotani, Kazuhiko Sakane, Naoki Sano, Yoshiko Tsuzaki, Kokoro Matsuoka, Yukiyo Egawa, Kahori Yoshimura, Makiko Horikawa, Chika Kitagawa, Yoshinori Kiso, Yoshinobu Kimura, Satoshi Schulze, John Taing, Jennifer Gugliucci, Alejandro |
author_sort | Kotani, Kazuhiko |
collection | PubMed |
description | Low caloric diet (LCD) is used for weight loss. Paraoxonase 1 (PON-1) is associated with the antioxidant functions of high-density lipoprotein (HDL). Among limited data on the relationships between obesity and PON-1, there has been no study on the effects of a stand-alone LCD on the physiological lactonase activity of PON-1. We investigated the prospective effects of LCD intervention (2 months) for weight loss on serum PON-1 activities (lactonase, arylesterase [mono-esterase] and tri-esterase) and HDL cholesterol (HDL-C), and their association with low-density lipoprotein cholesterol (LDL-C) in overweight and non-morbidly obese but otherwise healthy women (n = 30; mean age, 50.3 years; mean body mass index [BMI], 28.5 kg/m(2)). In addition to the data such as BMI, blood pressure, blood glucose and lipids, PON-1 activities were examined between pre- and post-intervention. The intervention reduced all metabolic outcomes, and PON-1 lactonase activity (determined with 5-[thiobutyl]butyrolactone) significantly decreased by 6.1%, paralleled by arylesterase (by 7.3%) and tri-esterase (by 7.8%). In multiple regression analysis, the percent change of PON-1 lactonase was significantly, positively and independently correlated to that of LDL-C (β = 0.51), HDL-C (β = 0.40), and BMI (β = 0.37). Our results showed that the solo diet treatment on weight loss might reduce serum PON-1 lactonase activity with reduced HDL-C and LDL-C. The relationship between the lactonase and LDL-C may be adaptive, plausibly hypothesizing less need for PON-1 activity as an antioxidant property to protect lipoproteins. Further research is needed to confirm this prediction. |
format | Text |
id | pubmed-2771255 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | the Society for Free Radical Research Japan |
record_format | MEDLINE/PubMed |
spelling | pubmed-27712552009-11-09 Changes on the Physiological Lactonase Activity of Serum Paraoxonase 1 by a Diet Intervention for Weight Loss in Healthy Overweight and Obese Women Kotani, Kazuhiko Sakane, Naoki Sano, Yoshiko Tsuzaki, Kokoro Matsuoka, Yukiyo Egawa, Kahori Yoshimura, Makiko Horikawa, Chika Kitagawa, Yoshinori Kiso, Yoshinobu Kimura, Satoshi Schulze, John Taing, Jennifer Gugliucci, Alejandro J Clin Biochem Nutr Original Article Low caloric diet (LCD) is used for weight loss. Paraoxonase 1 (PON-1) is associated with the antioxidant functions of high-density lipoprotein (HDL). Among limited data on the relationships between obesity and PON-1, there has been no study on the effects of a stand-alone LCD on the physiological lactonase activity of PON-1. We investigated the prospective effects of LCD intervention (2 months) for weight loss on serum PON-1 activities (lactonase, arylesterase [mono-esterase] and tri-esterase) and HDL cholesterol (HDL-C), and their association with low-density lipoprotein cholesterol (LDL-C) in overweight and non-morbidly obese but otherwise healthy women (n = 30; mean age, 50.3 years; mean body mass index [BMI], 28.5 kg/m(2)). In addition to the data such as BMI, blood pressure, blood glucose and lipids, PON-1 activities were examined between pre- and post-intervention. The intervention reduced all metabolic outcomes, and PON-1 lactonase activity (determined with 5-[thiobutyl]butyrolactone) significantly decreased by 6.1%, paralleled by arylesterase (by 7.3%) and tri-esterase (by 7.8%). In multiple regression analysis, the percent change of PON-1 lactonase was significantly, positively and independently correlated to that of LDL-C (β = 0.51), HDL-C (β = 0.40), and BMI (β = 0.37). Our results showed that the solo diet treatment on weight loss might reduce serum PON-1 lactonase activity with reduced HDL-C and LDL-C. The relationship between the lactonase and LDL-C may be adaptive, plausibly hypothesizing less need for PON-1 activity as an antioxidant property to protect lipoproteins. Further research is needed to confirm this prediction. the Society for Free Radical Research Japan 2009-11 2009-10-28 /pmc/articles/PMC2771255/ /pubmed/19902024 http://dx.doi.org/10.3164/jcbn.09-26 Text en Copyright © 2009 JCBN This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kotani, Kazuhiko Sakane, Naoki Sano, Yoshiko Tsuzaki, Kokoro Matsuoka, Yukiyo Egawa, Kahori Yoshimura, Makiko Horikawa, Chika Kitagawa, Yoshinori Kiso, Yoshinobu Kimura, Satoshi Schulze, John Taing, Jennifer Gugliucci, Alejandro Changes on the Physiological Lactonase Activity of Serum Paraoxonase 1 by a Diet Intervention for Weight Loss in Healthy Overweight and Obese Women |
title | Changes on the Physiological Lactonase Activity of Serum Paraoxonase 1 by a Diet Intervention for Weight Loss in Healthy Overweight and Obese Women |
title_full | Changes on the Physiological Lactonase Activity of Serum Paraoxonase 1 by a Diet Intervention for Weight Loss in Healthy Overweight and Obese Women |
title_fullStr | Changes on the Physiological Lactonase Activity of Serum Paraoxonase 1 by a Diet Intervention for Weight Loss in Healthy Overweight and Obese Women |
title_full_unstemmed | Changes on the Physiological Lactonase Activity of Serum Paraoxonase 1 by a Diet Intervention for Weight Loss in Healthy Overweight and Obese Women |
title_short | Changes on the Physiological Lactonase Activity of Serum Paraoxonase 1 by a Diet Intervention for Weight Loss in Healthy Overweight and Obese Women |
title_sort | changes on the physiological lactonase activity of serum paraoxonase 1 by a diet intervention for weight loss in healthy overweight and obese women |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771255/ https://www.ncbi.nlm.nih.gov/pubmed/19902024 http://dx.doi.org/10.3164/jcbn.09-26 |
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