Potent New Small-Molecule Inhibitor of Botulinum Neurotoxin Serotype A Endopeptidase Developed by Synthesis-Based Computer-Aided Molecular Design

Botulinum neurotoxin serotype A (BoNTA) causes a life-threatening neuroparalytic disease known as botulism. Current treatment for post exposure of BoNTA uses antibodies that are effective in neutralizing the extracellular toxin to prevent further intoxication but generally cannot rescue already into...

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Detalles Bibliográficos
Autores principales: Pang, Yuan-Ping, Vummenthala, Anuradha, Mishra, Rajesh K., Park, Jewn Giew, Wang, Shaohua, Davis, Jon, Millard, Charles B., Schmidt, James J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771286/
https://www.ncbi.nlm.nih.gov/pubmed/19901994
http://dx.doi.org/10.1371/journal.pone.0007730

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