Exploitation of binding energy for catalysis and design

Enzymes utilize substrate binding energy both to promote ground state association and to selectively lower the energy of the reaction transition state.i The monomeric homing endonuclease I-AniI cleaves with high sequence specificity in the center of a 20 base-pair DNA target site, with the N-termina...

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Detalles Bibliográficos
Autores principales: Thyme, Summer B., Jarjour, Jordan, Takeuchi, Ryo, Havranek, James J., Ashworth, Justin, Scharenberg, Andrew M., Stoddard, Barry L., Baker, David
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771326/
https://www.ncbi.nlm.nih.gov/pubmed/19865174
http://dx.doi.org/10.1038/nature08508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771326/
https://www.ncbi.nlm.nih.gov/pubmed/19865174
http://dx.doi.org/10.1038/nature08508

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