Cargando…

Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages

The dual specificity phosphatase 6 (Dusp6) functions as a feedback regulator of fibroblast growth factor (FGF) signaling to limit the activity of extracellular signal regulated kinase (ERK) 1 and 2. We have identified a small molecule inhibitor of Dusp6, (E)-2-benzylidene-3-(cyclohexylamino)-2,3-dih...

Descripción completa

Detalles Bibliográficos
Autores principales:	Molina, Gabriela, Vogt, Andreas, Bakan, Ahmet, Dai, Weixiang, de Oliveira, Pierre Queiroz, Znosko, Wade, Smithgall, Thomas E., Bahar, Ivet, Lazo, John S., Day, Billy W., Tsang, Michael
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771339/ https://www.ncbi.nlm.nih.gov/pubmed/19578332 http://dx.doi.org/10.1038/nchembio.190

Ejemplares similares

Toward a Molecular Understanding of the Interaction of Dual Specificity Phosphatases with Substrates: Insights from Structure-Based Modeling and High Throughput Screening
por: Bakan, Ahmet, et al.
Publicado: (2008)

Development of automated imaging and analysis for zebrafish chemical screens.
por: Vogt, Andreas, et al.
Publicado: (2010)

ProDy: Protein Dynamics Inferred from Theory and Experiments
por: Bakan, Ahmet, et al.
Publicado: (2011)

Druggability Assessment of Allosteric Proteins by Dynamics Simulations in the Presence of Probe Molecules
por: Bakan, Ahmet, et al.
Publicado: (2012)

Coupling between Catalytic Loop Motions and Enzyme Global Dynamics
por: Kurkcuoglu, Zeynep, et al.
Publicado: (2012)

Dusp1 regulates thermal tolerance limits in zebrafish by maintaining mitochondrial integrity
por: Wang, Ying, et al.
Publicado: (2023)

Generation of FGF reporter transgenic zebrafish and their utility in chemical screens
por: Molina, Gabriela A, et al.
Publicado: (2007)

NEAP/DUSP26 suppresses receptor tyrosine kinases and regulates neuronal development in zebrafish
por: Yang, Chi-Hwa, et al.
Publicado: (2017)

DUSP5 and DUSP6 modulate corneal epithelial cell proliferation
por: Wang, Zheng, et al.
Publicado: (2010)

Specialized Motor-Driven dusp1 Expression in the Song Systems of Multiple Lineages of Vocal Learning Birds
por: Horita, Haruhito, et al.
Publicado: (2012)

DUSPs, to MAP kinases and beyond
por: Huang, Ching-Yu, et al.
Publicado: (2012)

DUSP2 deletion with CRISPR/Cas9 promotes Mauthner cell axonal regeneration at the early stage of zebrafish
por: Shao, Guo-Jian, et al.
Publicado: (2022)

The cytotoxic action of BCI is not dependent on its stated DUSP1 or DUSP6 targets in neuroblastoma cells
por: Thompson, Elliott M., et al.
Publicado: (2022)

DUSP4 phosphatase puts the brakes on DLBCL
por: Rickert, Robert
Publicado: (2015)

Proapoptotic function of deubiquitinase DUSP31 in Drosophila
por: Sinenko, Sergey A.
Publicado: (2017)

Investigating the Role of DUSP4 in Uveal Melanoma
por: Aughton, Karen, et al.
Publicado: (2022)

On the functional significance of soft modes predicted by coarse-grained models for membrane proteins
por: Bahar, Ivet
Publicado: (2010)

DUSP12 regulates the tumorigenesis and prognosis of hepatocellular carcinoma
por: Ju, Gaoda, et al.
Publicado: (2021)

DUSP5 and DUSP6, two ERK specific phosphatases, are markers of a higher MAPK signaling activation in BRAF mutated thyroid cancers
por: Buffet, Camille, et al.
Publicado: (2017)

SARS-CoV-2 Switches ‘on’ MAPK and NFκB Signaling via the Reduction of Nuclear DUSP1 and DUSP5 Expression
por: Goel, Swati, et al.
Publicado: (2021)

BCI, an inhibitor of the DUSP1 and DUSP6 dual specificity phosphatases, enhances P2X7 receptor expression in neuroblastoma cells
por: Benito-León, María, et al.
Publicado: (2022)

QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics
por: Li, Hongchun, et al.
Publicado: (2020)

Heritable and Lineage-Specific Gene Knockdown in Zebrafish Embryo
por: Dong, Mei, et al.
Publicado: (2009)

Efficient knock-in method enabling lineage tracing in zebrafish
por: Mi, Jiarui, et al.
Publicado: (2023)

Social Determinants modulate NK cell activity via obesity, LDL, and DUSP1 signaling
por: Baumer, Yvonne, et al.
Publicado: (2023)

Involvement of the Cellular Phosphatase DUSP1 in Vaccinia Virus Infection
por: Cáceres, Ana, et al.
Publicado: (2013)

DUSP1 is involved in the progression of small cell carcinoma of the prostate
por: Zhang, Yajing, et al.
Publicado: (2018)

Revisiting the roles of VHR/DUSP3 phosphatase in human diseases
por: Russo, Lilian Cristina, et al.
Publicado: (2018)

Regulation of Dual-Specificity Phosphatase (DUSP) Ubiquitination and Protein Stability
por: Chen, Hsueh-Fen, et al.
Publicado: (2019)

Dusp8 affects hippocampal size and behavior in mice and humans
por: Baumann, Peter, et al.
Publicado: (2019)

DUSP11 and triphosphate RNA balance during virus infection
por: Choi, Joon H., et al.
Publicado: (2021)

Expanding the CRISPR Toolbox in Zebrafish for Studying Development and Disease
por: Liu, Kaili, et al.
Publicado: (2019)

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity
por: Li, Guangjin, et al.
Publicado: (2012)

Markov propagation of allosteric effects in biomolecular systems: application to GroEL–GroES
por: Chennubhotla, Chakra, et al.
Publicado: (2006)

Signal Propagation in Proteins and Relation to Equilibrium Fluctuations
por: Chennubhotla, Chakra, et al.
Publicado: (2007)

Recruitment of rare 3-grams at functional sites: Is this a mechanism for increasing enzyme specificity?
por: Tobi, Dror, et al.
Publicado: (2007)

Correction: Signal Propagation in Proteins and Relation to Equilibrium Fluctuations
por: Chennubhotla, Chakra, et al.
Publicado: (2007)

A Conformational Switch in a Partially Unwound Helix Selectively Determines the Pathway for Substrate Release from the Carnitine/γ-Butyrobetaine Antiporter CaiT
por: Zomot, Elia, et al.
Publicado: (2012)

Sequence Evolution Correlates with Structural Dynamics
por: Liu, Ying, et al.
Publicado: (2012)

Intracellular Gating in an Inward-facing State of Aspartate Transporter Glt(Ph) Is Regulated by the Movements of the Helical Hairpin HP2
por: Zomot, Elia, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_271t2fjbjo975p1jo1st0fp3uv