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Potential Benefits of Sequential Inhibitor-Mutagen Treatments of RNA Virus Infections

Lethal mutagenesis is an antiviral strategy consisting of virus extinction associated with enhanced mutagenesis. The use of non-mutagenic antiviral inhibitors has faced the problem of selection of inhibitor-resistant virus mutants. Quasispecies dynamics predicts, and clinical results have confirmed,...

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Detalles Bibliográficos
Autores principales:	Perales, Celia, Agudo, Rubén, Tejero, Hector, Manrubia, Susanna C., Domingo, Esteban
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771356/ https://www.ncbi.nlm.nih.gov/pubmed/19911056 http://dx.doi.org/10.1371/journal.ppat.1000658

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