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Effects of Genital Ulcer Disease and Herpes Simplex Virus Type 2 on the Efficacy of Male Circumcision for HIV Prevention: Analyses from the Rakai Trials

BACKGROUND: Randomized trials show that male circumcision (MC) reduces the incidence of HIV and herpes simplex virus type 2 (HSV-2) infections, and symptomatic genital ulcer disease (GUD). We assessed the role of GUD and HSV-2 in the protection against HIV afforded by MC. METHODS AND FINDINGS: HIV-u...

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Detalles Bibliográficos
Autores principales: Gray, Ronald H., Serwadda, David, Tobian, Aaron A. R., Chen, Michael Z., Makumbi, Frederick, Suntoke, Tara, Kigozi, Godfrey, Nalugoda, Fred, Iga, Boaz, Quinn, Thomas C., Moulton, Lawrence H., Laeyendecker, Oliver, Reynolds, Steven J., Kong, Xiangrong, Wawer, Maria J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771764/
https://www.ncbi.nlm.nih.gov/pubmed/19936044
http://dx.doi.org/10.1371/journal.pmed.1000187