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Acute and Subacute Stent Thrombosis in a Patient With Clopidogrel Resistance: A Case Report
Drug-eluting stents (DES) are considered the treatment of choice for most patients with obstructive coronary artery disease when percutaneous intervention (PCI) is feasible. However, stent thrombosis seems to occur more frequently with DES and occasionally is associated with resistance to anti-plate...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Korean Society of Cardiology
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771795/ https://www.ncbi.nlm.nih.gov/pubmed/19949590 http://dx.doi.org/10.4070/kcj.2009.39.10.434 |
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author | Kim, Sung Soo Jeong, Myung Ho Kim, Hyun-Kuk Bae, Soo Young Ryu, Kyoung Ho Cho, Kyung Hun Kim, Min Chul Park, Keun Ho Sim, Doo Sun Hong, Young Joon Kim, Ju Han Ahn, Youngkeun Kang, Jung Chaee |
author_facet | Kim, Sung Soo Jeong, Myung Ho Kim, Hyun-Kuk Bae, Soo Young Ryu, Kyoung Ho Cho, Kyung Hun Kim, Min Chul Park, Keun Ho Sim, Doo Sun Hong, Young Joon Kim, Ju Han Ahn, Youngkeun Kang, Jung Chaee |
author_sort | Kim, Sung Soo |
collection | PubMed |
description | Drug-eluting stents (DES) are considered the treatment of choice for most patients with obstructive coronary artery disease when percutaneous intervention (PCI) is feasible. However, stent thrombosis seems to occur more frequently with DES and occasionally is associated with resistance to anti-platelet drugs. We have experienced a case of recurrent stent thrombosis in a patient with clopidogrel resistance. A 63-year-old female patient suffered from acute myocardial infarction and underwent successful PCI of the left anterior descending coronary artery (LAD) with two DESs. She was found to be hyporesponsive to clopidogrel and was treated with triple anti-platelet therapy (aspirin 100 mg, clopidogrel 75 mg, and cilostazol 200 mg daily). Three days after discharge, she developed chest pain and was again taken to the cardiac catheterization laboratory, where coronary angiography (CAG) showed total occlusion of the mid-LAD where the stent had been placed. After intravenous administration of a glycoprotein IIb/IIIa inhibitor, balloon angioplasty was performed, resulting in Thrombolysis In Myocardial Infarction (TIMI) III antegrade flow. The next day, however, she complained of severe chest pain, and the electrocardiogram showed marked ST-segment elevation in V1-V6, I, and aVL with complete right bundle branch block. Emergent CAG revealed total occlusion of the proximal LAD due to stent thrombosis. She was successfully treated with balloon angioplasty and was discharged with triple anti-platelet therapy. |
format | Text |
id | pubmed-2771795 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | The Korean Society of Cardiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-27717952009-11-30 Acute and Subacute Stent Thrombosis in a Patient With Clopidogrel Resistance: A Case Report Kim, Sung Soo Jeong, Myung Ho Kim, Hyun-Kuk Bae, Soo Young Ryu, Kyoung Ho Cho, Kyung Hun Kim, Min Chul Park, Keun Ho Sim, Doo Sun Hong, Young Joon Kim, Ju Han Ahn, Youngkeun Kang, Jung Chaee Korean Circ J Case Report Drug-eluting stents (DES) are considered the treatment of choice for most patients with obstructive coronary artery disease when percutaneous intervention (PCI) is feasible. However, stent thrombosis seems to occur more frequently with DES and occasionally is associated with resistance to anti-platelet drugs. We have experienced a case of recurrent stent thrombosis in a patient with clopidogrel resistance. A 63-year-old female patient suffered from acute myocardial infarction and underwent successful PCI of the left anterior descending coronary artery (LAD) with two DESs. She was found to be hyporesponsive to clopidogrel and was treated with triple anti-platelet therapy (aspirin 100 mg, clopidogrel 75 mg, and cilostazol 200 mg daily). Three days after discharge, she developed chest pain and was again taken to the cardiac catheterization laboratory, where coronary angiography (CAG) showed total occlusion of the mid-LAD where the stent had been placed. After intravenous administration of a glycoprotein IIb/IIIa inhibitor, balloon angioplasty was performed, resulting in Thrombolysis In Myocardial Infarction (TIMI) III antegrade flow. The next day, however, she complained of severe chest pain, and the electrocardiogram showed marked ST-segment elevation in V1-V6, I, and aVL with complete right bundle branch block. Emergent CAG revealed total occlusion of the proximal LAD due to stent thrombosis. She was successfully treated with balloon angioplasty and was discharged with triple anti-platelet therapy. The Korean Society of Cardiology 2009-10 2009-10-28 /pmc/articles/PMC2771795/ /pubmed/19949590 http://dx.doi.org/10.4070/kcj.2009.39.10.434 Text en Copyright © 2009 The Korean Society of Cardiology http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Kim, Sung Soo Jeong, Myung Ho Kim, Hyun-Kuk Bae, Soo Young Ryu, Kyoung Ho Cho, Kyung Hun Kim, Min Chul Park, Keun Ho Sim, Doo Sun Hong, Young Joon Kim, Ju Han Ahn, Youngkeun Kang, Jung Chaee Acute and Subacute Stent Thrombosis in a Patient With Clopidogrel Resistance: A Case Report |
title | Acute and Subacute Stent Thrombosis in a Patient With Clopidogrel Resistance: A Case Report |
title_full | Acute and Subacute Stent Thrombosis in a Patient With Clopidogrel Resistance: A Case Report |
title_fullStr | Acute and Subacute Stent Thrombosis in a Patient With Clopidogrel Resistance: A Case Report |
title_full_unstemmed | Acute and Subacute Stent Thrombosis in a Patient With Clopidogrel Resistance: A Case Report |
title_short | Acute and Subacute Stent Thrombosis in a Patient With Clopidogrel Resistance: A Case Report |
title_sort | acute and subacute stent thrombosis in a patient with clopidogrel resistance: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771795/ https://www.ncbi.nlm.nih.gov/pubmed/19949590 http://dx.doi.org/10.4070/kcj.2009.39.10.434 |
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