Is Stem Cell-Based Therapy Going on or Out for Cardiac Disease?

Acute myocardial infarction and subsequent heart failure are leading causes of death worldwide. Stem cell-based therapies have improved cardiac function in recent clinical trials, but cardiomyocyte regeneration has not been demonstrated in human hearts. Angiogenesis and restoration of cardiac perfus...

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Detalles Bibliográficos
Autores principales: Byun, Ki Hyun, Kim, Sung-Whan
Formato: Texto
Lenguaje:English
Publicado: The Korean Society of Cardiology 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771799/
https://www.ncbi.nlm.nih.gov/pubmed/19949592
http://dx.doi.org/10.4070/kcj.2009.39.3.87
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author Byun, Ki Hyun
Kim, Sung-Whan
author_facet Byun, Ki Hyun
Kim, Sung-Whan
author_sort Byun, Ki Hyun
collection PubMed
description Acute myocardial infarction and subsequent heart failure are leading causes of death worldwide. Stem cell-based therapies have improved cardiac function in recent clinical trials, but cardiomyocyte regeneration has not been demonstrated in human hearts. Angiogenesis and restoration of cardiac perfusion have been successfully performed using bone marrow derived stem cells and other adult stem cells. Resident cardiac stem cells are known to differentiate into multiple heart cell types, including cardiomyocytes. Furthermore, induced pluripotent stem cells are a focus of research due to the great potential for customized stem cell therapy.
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spelling pubmed-27717992009-11-30 Is Stem Cell-Based Therapy Going on or Out for Cardiac Disease? Byun, Ki Hyun Kim, Sung-Whan Korean Circ J Review Acute myocardial infarction and subsequent heart failure are leading causes of death worldwide. Stem cell-based therapies have improved cardiac function in recent clinical trials, but cardiomyocyte regeneration has not been demonstrated in human hearts. Angiogenesis and restoration of cardiac perfusion have been successfully performed using bone marrow derived stem cells and other adult stem cells. Resident cardiac stem cells are known to differentiate into multiple heart cell types, including cardiomyocytes. Furthermore, induced pluripotent stem cells are a focus of research due to the great potential for customized stem cell therapy. The Korean Society of Cardiology 2009-03 2009-03-25 /pmc/articles/PMC2771799/ /pubmed/19949592 http://dx.doi.org/10.4070/kcj.2009.39.3.87 Text en Copyright © 2009 The Korean Society of Cardiology http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Byun, Ki Hyun
Kim, Sung-Whan
Is Stem Cell-Based Therapy Going on or Out for Cardiac Disease?
title Is Stem Cell-Based Therapy Going on or Out for Cardiac Disease?
title_full Is Stem Cell-Based Therapy Going on or Out for Cardiac Disease?
title_fullStr Is Stem Cell-Based Therapy Going on or Out for Cardiac Disease?
title_full_unstemmed Is Stem Cell-Based Therapy Going on or Out for Cardiac Disease?
title_short Is Stem Cell-Based Therapy Going on or Out for Cardiac Disease?
title_sort is stem cell-based therapy going on or out for cardiac disease?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771799/
https://www.ncbi.nlm.nih.gov/pubmed/19949592
http://dx.doi.org/10.4070/kcj.2009.39.3.87
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