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An autopsy report on multiple system atrophy diagnosed immunohistochemically despite severe ischaemic damage: a new approach for investigation of medical practice associated deaths in Japan
A 60-year old man with a 10-year history of multiple system atrophy (MSA) was found in respiratory arrest. After 4 months of respiratory support with two episodes of septic shock, he died. Autopsy disclosed severe atrophy of the mesencephalon, brainstem, medulla oblongata and cerebellum. Gallyas–Bra...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BMJ Group
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771852/ https://www.ncbi.nlm.nih.gov/pubmed/19861562 http://dx.doi.org/10.1136/jcp.2009.065060 |
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author | Nakajima, M Kojima, H Takazawa, Y Yahagi, N Harada, K Takahashi, K Unuma, K Yoshida, K |
author_facet | Nakajima, M Kojima, H Takazawa, Y Yahagi, N Harada, K Takahashi, K Unuma, K Yoshida, K |
author_sort | Nakajima, M |
collection | PubMed |
description | A 60-year old man with a 10-year history of multiple system atrophy (MSA) was found in respiratory arrest. After 4 months of respiratory support with two episodes of septic shock, he died. Autopsy disclosed severe atrophy of the mesencephalon, brainstem, medulla oblongata and cerebellum. Gallyas–Braak, α-synuclein and ubiquitin-positive inclusions in the cytoplasm of glial cells were evident, despite the severe ischaemic damage due to respiratory arrest and subsequent respiratory support for 4 months. The cause of respiratory arrest was not identified, but could be explained by the natural history of MSA. The bereaved family, who had suspected malpractice, was satisfied with the explanation based on the investigation performed by eight expert doctors, one expert nurse, two coordinator nurses and two lawyers in the model project promoted by the Japanese government. |
format | Text |
id | pubmed-2771852 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BMJ Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-27718522009-11-16 An autopsy report on multiple system atrophy diagnosed immunohistochemically despite severe ischaemic damage: a new approach for investigation of medical practice associated deaths in Japan Nakajima, M Kojima, H Takazawa, Y Yahagi, N Harada, K Takahashi, K Unuma, K Yoshida, K J Clin Pathol Case Reports A 60-year old man with a 10-year history of multiple system atrophy (MSA) was found in respiratory arrest. After 4 months of respiratory support with two episodes of septic shock, he died. Autopsy disclosed severe atrophy of the mesencephalon, brainstem, medulla oblongata and cerebellum. Gallyas–Braak, α-synuclein and ubiquitin-positive inclusions in the cytoplasm of glial cells were evident, despite the severe ischaemic damage due to respiratory arrest and subsequent respiratory support for 4 months. The cause of respiratory arrest was not identified, but could be explained by the natural history of MSA. The bereaved family, who had suspected malpractice, was satisfied with the explanation based on the investigation performed by eight expert doctors, one expert nurse, two coordinator nurses and two lawyers in the model project promoted by the Japanese government. BMJ Group 2009-11 2009-10-20 /pmc/articles/PMC2771852/ /pubmed/19861562 http://dx.doi.org/10.1136/jcp.2009.065060 Text en © Nakajima et al 2009 http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Reports Nakajima, M Kojima, H Takazawa, Y Yahagi, N Harada, K Takahashi, K Unuma, K Yoshida, K An autopsy report on multiple system atrophy diagnosed immunohistochemically despite severe ischaemic damage: a new approach for investigation of medical practice associated deaths in Japan |
title | An autopsy report on multiple system atrophy diagnosed immunohistochemically despite severe ischaemic damage: a new approach for investigation of medical practice associated deaths in Japan |
title_full | An autopsy report on multiple system atrophy diagnosed immunohistochemically despite severe ischaemic damage: a new approach for investigation of medical practice associated deaths in Japan |
title_fullStr | An autopsy report on multiple system atrophy diagnosed immunohistochemically despite severe ischaemic damage: a new approach for investigation of medical practice associated deaths in Japan |
title_full_unstemmed | An autopsy report on multiple system atrophy diagnosed immunohistochemically despite severe ischaemic damage: a new approach for investigation of medical practice associated deaths in Japan |
title_short | An autopsy report on multiple system atrophy diagnosed immunohistochemically despite severe ischaemic damage: a new approach for investigation of medical practice associated deaths in Japan |
title_sort | autopsy report on multiple system atrophy diagnosed immunohistochemically despite severe ischaemic damage: a new approach for investigation of medical practice associated deaths in japan |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771852/ https://www.ncbi.nlm.nih.gov/pubmed/19861562 http://dx.doi.org/10.1136/jcp.2009.065060 |
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