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Dramatic Co-Activation of WWOX/WOX1 with CREB and NF-κB in Delayed Loss of Small Dorsal Root Ganglion Neurons upon Sciatic Nerve Transection in Rats
BACKGROUND: Tumor suppressor WOX1 (also named WWOX or FOR) is known to participate in neuronal apoptosis in vivo. Here, we investigated the functional role of WOX1 and transcription factors in the delayed loss of axotomized neurons in dorsal root ganglia (DRG) in rats. METHODOLOGY/PRINCIPAL FINDINGS...
Autores principales: | Li, Meng-Yen, Lai, Feng-Jie, Hsu, Li-Jin, Lo, Chen-Peng, Cheng, Ching-Li, Lin, Sing-Ru, Lee, Ming-Hui, Chang, Jean-Yun, Subhan, Dudekula, Tsai, Ming-Shu, Sze, Chun-I, Pugazhenthi, Subbiah, Chang, Nan-Shan, Chen, Shur-Tzu |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771921/ https://www.ncbi.nlm.nih.gov/pubmed/19918364 http://dx.doi.org/10.1371/journal.pone.0007820 |
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