Magnetic resonance imaging may simulate progressive multifocal leucoencephalopathy in a patient with chronic lymphocytic leukemia after fludarabine therapy

A 60-year-old male with chronic lymphatic leukemia (CLL) after 6 months of fludarabine therapy was admitted with status epilepticus and developed left hemiplegia. His magnetic resonance imaging revealed multiple T2 hyperintense lesions in the right frontal and left parieto-occipital lesion, simulati...

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Autores principales: Kalita, J., Patel, N. S., Misra, U. K.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2008
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771959/
https://www.ncbi.nlm.nih.gov/pubmed/19893650
http://dx.doi.org/10.4103/0972-2327.41880
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author Kalita, J.
Patel, N. S.
Misra, U. K.
author_facet Kalita, J.
Patel, N. S.
Misra, U. K.
author_sort Kalita, J.
collection PubMed
description A 60-year-old male with chronic lymphatic leukemia (CLL) after 6 months of fludarabine therapy was admitted with status epilepticus and developed left hemiplegia. His magnetic resonance imaging revealed multiple T2 hyperintense lesions in the right frontal and left parieto-occipital lesion, simulating progressive multifocal leucoencephalopathy (PML). Cerebrospinal fluid Polymerase Chain Reaction (PCR) for JC virus was negative. We suggest the possible role of fludarabine in producing PML-like lesions in patients with Chronic Lymphocytic Leukemia (CLL).
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spelling pubmed-27719592009-11-05 Magnetic resonance imaging may simulate progressive multifocal leucoencephalopathy in a patient with chronic lymphocytic leukemia after fludarabine therapy Kalita, J. Patel, N. S. Misra, U. K. Ann Indian Acad Neurol Case Report A 60-year-old male with chronic lymphatic leukemia (CLL) after 6 months of fludarabine therapy was admitted with status epilepticus and developed left hemiplegia. His magnetic resonance imaging revealed multiple T2 hyperintense lesions in the right frontal and left parieto-occipital lesion, simulating progressive multifocal leucoencephalopathy (PML). Cerebrospinal fluid Polymerase Chain Reaction (PCR) for JC virus was negative. We suggest the possible role of fludarabine in producing PML-like lesions in patients with Chronic Lymphocytic Leukemia (CLL). Medknow Publications 2008 /pmc/articles/PMC2771959/ /pubmed/19893650 http://dx.doi.org/10.4103/0972-2327.41880 Text en © Annals of Indian Academy of Neurology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kalita, J.
Patel, N. S.
Misra, U. K.
Magnetic resonance imaging may simulate progressive multifocal leucoencephalopathy in a patient with chronic lymphocytic leukemia after fludarabine therapy
title Magnetic resonance imaging may simulate progressive multifocal leucoencephalopathy in a patient with chronic lymphocytic leukemia after fludarabine therapy
title_full Magnetic resonance imaging may simulate progressive multifocal leucoencephalopathy in a patient with chronic lymphocytic leukemia after fludarabine therapy
title_fullStr Magnetic resonance imaging may simulate progressive multifocal leucoencephalopathy in a patient with chronic lymphocytic leukemia after fludarabine therapy
title_full_unstemmed Magnetic resonance imaging may simulate progressive multifocal leucoencephalopathy in a patient with chronic lymphocytic leukemia after fludarabine therapy
title_short Magnetic resonance imaging may simulate progressive multifocal leucoencephalopathy in a patient with chronic lymphocytic leukemia after fludarabine therapy
title_sort magnetic resonance imaging may simulate progressive multifocal leucoencephalopathy in a patient with chronic lymphocytic leukemia after fludarabine therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771959/
https://www.ncbi.nlm.nih.gov/pubmed/19893650
http://dx.doi.org/10.4103/0972-2327.41880
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AT patelns magneticresonanceimagingmaysimulateprogressivemultifocalleucoencephalopathyinapatientwithchroniclymphocyticleukemiaafterfludarabinetherapy
AT misrauk magneticresonanceimagingmaysimulateprogressivemultifocalleucoencephalopathyinapatientwithchroniclymphocyticleukemiaafterfludarabinetherapy

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