ALEFACEPT PROMOTES COSTIMULATION BLOCKADE BASED ALLOGRAFT SURVIVAL IN PRIMATES

Memory T-cells promote allograft rejection particularly in costimulation blockade (CoB)-based immunosuppressive regimens. Here we show that the CD2-specific fusion protein alefacept (LFA3-Ig) selectively eliminates memory T-cells and when combined with a CoB-based regimen utilizing CTLA4-Ig, prevent...

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Autores principales: Weaver, T.A., Charafeddine, A.H., Agarwal, A., Turner, A.P., Russell, M., Leopardi, F.V., Kampen, R.L., Stempora, L., Song, M., Larsen, C.P., Kirk, A.D.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772128/
https://www.ncbi.nlm.nih.gov/pubmed/19584865
http://dx.doi.org/10.1038/nm.1993
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author Weaver, T.A.
Charafeddine, A.H.
Agarwal, A.
Turner, A.P.
Russell, M.
Leopardi, F.V.
Kampen, R.L.
Stempora, L.
Song, M.
Larsen, C.P.
Kirk, A.D.
author_facet Weaver, T.A.
Charafeddine, A.H.
Agarwal, A.
Turner, A.P.
Russell, M.
Leopardi, F.V.
Kampen, R.L.
Stempora, L.
Song, M.
Larsen, C.P.
Kirk, A.D.
author_sort Weaver, T.A.
collection PubMed
description Memory T-cells promote allograft rejection particularly in costimulation blockade (CoB)-based immunosuppressive regimens. Here we show that the CD2-specific fusion protein alefacept (LFA3-Ig) selectively eliminates memory T-cells and when combined with a CoB-based regimen utilizing CTLA4-Ig, prevents renal allograft rejection and alloantibody formation in primates. These results support the development of an immediately translatable regimen for the prevention of allograft rejection without the use of calcineurin inhibitors, steroids, or pan-T-cell depletion.
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spelling pubmed-27721282010-01-05 ALEFACEPT PROMOTES COSTIMULATION BLOCKADE BASED ALLOGRAFT SURVIVAL IN PRIMATES Weaver, T.A. Charafeddine, A.H. Agarwal, A. Turner, A.P. Russell, M. Leopardi, F.V. Kampen, R.L. Stempora, L. Song, M. Larsen, C.P. Kirk, A.D. Nat Med Article Memory T-cells promote allograft rejection particularly in costimulation blockade (CoB)-based immunosuppressive regimens. Here we show that the CD2-specific fusion protein alefacept (LFA3-Ig) selectively eliminates memory T-cells and when combined with a CoB-based regimen utilizing CTLA4-Ig, prevents renal allograft rejection and alloantibody formation in primates. These results support the development of an immediately translatable regimen for the prevention of allograft rejection without the use of calcineurin inhibitors, steroids, or pan-T-cell depletion. 2009-07-05 2009-07 /pmc/articles/PMC2772128/ /pubmed/19584865 http://dx.doi.org/10.1038/nm.1993 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Weaver, T.A.
Charafeddine, A.H.
Agarwal, A.
Turner, A.P.
Russell, M.
Leopardi, F.V.
Kampen, R.L.
Stempora, L.
Song, M.
Larsen, C.P.
Kirk, A.D.
ALEFACEPT PROMOTES COSTIMULATION BLOCKADE BASED ALLOGRAFT SURVIVAL IN PRIMATES
title ALEFACEPT PROMOTES COSTIMULATION BLOCKADE BASED ALLOGRAFT SURVIVAL IN PRIMATES
title_full ALEFACEPT PROMOTES COSTIMULATION BLOCKADE BASED ALLOGRAFT SURVIVAL IN PRIMATES
title_fullStr ALEFACEPT PROMOTES COSTIMULATION BLOCKADE BASED ALLOGRAFT SURVIVAL IN PRIMATES
title_full_unstemmed ALEFACEPT PROMOTES COSTIMULATION BLOCKADE BASED ALLOGRAFT SURVIVAL IN PRIMATES
title_short ALEFACEPT PROMOTES COSTIMULATION BLOCKADE BASED ALLOGRAFT SURVIVAL IN PRIMATES
title_sort alefacept promotes costimulation blockade based allograft survival in primates
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772128/
https://www.ncbi.nlm.nih.gov/pubmed/19584865
http://dx.doi.org/10.1038/nm.1993
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