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ALEFACEPT PROMOTES COSTIMULATION BLOCKADE BASED ALLOGRAFT SURVIVAL IN PRIMATES

Memory T-cells promote allograft rejection particularly in costimulation blockade (CoB)-based immunosuppressive regimens. Here we show that the CD2-specific fusion protein alefacept (LFA3-Ig) selectively eliminates memory T-cells and when combined with a CoB-based regimen utilizing CTLA4-Ig, prevent...

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Detalles Bibliográficos
Autores principales:	Weaver, T.A., Charafeddine, A.H., Agarwal, A., Turner, A.P., Russell, M., Leopardi, F.V., Kampen, R.L., Stempora, L., Song, M., Larsen, C.P., Kirk, A.D.
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772128/ https://www.ncbi.nlm.nih.gov/pubmed/19584865 http://dx.doi.org/10.1038/nm.1993

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