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Adrenocortical Responsiveness to Infusions of Physiological Doses of ACTH is not Altered in Posttraumatic Stress Disorder
Early studies of posttraumatic stress disorder (PTSD) reported that abnormal function of the hypothalamic–pituitary–adrenocortical (HPA) system was associated with the disorder. However, subsequent studies attempting to identify a specific aspect of HPA dysfunction that characterizes PTSD have been...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Frontiers Research Foundation
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773172/ https://www.ncbi.nlm.nih.gov/pubmed/19893760 http://dx.doi.org/10.3389/neuro.08.040.2009 |
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author | Radant, Allen D. Dobie, Dorcas J. Peskind, Elaine R. Murburg, M. Michele Petrie, Eric C. Kanter, Evan D. Raskind, Murray A. Wilkinson, Charles W. |
author_facet | Radant, Allen D. Dobie, Dorcas J. Peskind, Elaine R. Murburg, M. Michele Petrie, Eric C. Kanter, Evan D. Raskind, Murray A. Wilkinson, Charles W. |
author_sort | Radant, Allen D. |
collection | PubMed |
description | Early studies of posttraumatic stress disorder (PTSD) reported that abnormal function of the hypothalamic–pituitary–adrenocortical (HPA) system was associated with the disorder. However, subsequent studies attempting to identify a specific aspect of HPA dysfunction that characterizes PTSD have been marked by considerable inconsistency of results. A facet of HPA regulation that has been considered but not definitively investigated is the possibility that the responsiveness of the adrenal cortex to physiological concentrations of adrenocorticotropin (ACTH) is diminished in PTSD. Relationships between PTSD and the adrenal androgen dehydroepiandrosterone (DHEA) have also been postulated. In this study we investigated the magnitude and time course of changes in concentrations of plasma cortisol and DHEA in response to bolus infusions of physiological doses of ACTH (1–24) in PTSD patients and control subjects. We found no evidence for PTSD-related alterations in cortisol or DHEA secretion in response to stimulation by low doses of ACTH and conclude that adrenocortical responsiveness is normal in PTSD. Results from this and other studies suggest that the occurrence of defects in HPA function in PTSD may be specific responses to particular combinations of trauma type, genetic susceptibility, and individual history. |
format | Text |
id | pubmed-2773172 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-27731722009-11-05 Adrenocortical Responsiveness to Infusions of Physiological Doses of ACTH is not Altered in Posttraumatic Stress Disorder Radant, Allen D. Dobie, Dorcas J. Peskind, Elaine R. Murburg, M. Michele Petrie, Eric C. Kanter, Evan D. Raskind, Murray A. Wilkinson, Charles W. Front Behav Neurosci Neuroscience Early studies of posttraumatic stress disorder (PTSD) reported that abnormal function of the hypothalamic–pituitary–adrenocortical (HPA) system was associated with the disorder. However, subsequent studies attempting to identify a specific aspect of HPA dysfunction that characterizes PTSD have been marked by considerable inconsistency of results. A facet of HPA regulation that has been considered but not definitively investigated is the possibility that the responsiveness of the adrenal cortex to physiological concentrations of adrenocorticotropin (ACTH) is diminished in PTSD. Relationships between PTSD and the adrenal androgen dehydroepiandrosterone (DHEA) have also been postulated. In this study we investigated the magnitude and time course of changes in concentrations of plasma cortisol and DHEA in response to bolus infusions of physiological doses of ACTH (1–24) in PTSD patients and control subjects. We found no evidence for PTSD-related alterations in cortisol or DHEA secretion in response to stimulation by low doses of ACTH and conclude that adrenocortical responsiveness is normal in PTSD. Results from this and other studies suggest that the occurrence of defects in HPA function in PTSD may be specific responses to particular combinations of trauma type, genetic susceptibility, and individual history. Frontiers Research Foundation 2009-10-30 /pmc/articles/PMC2773172/ /pubmed/19893760 http://dx.doi.org/10.3389/neuro.08.040.2009 Text en Copyright © 2009 Radant, Dobie, Peskind, Murburg, Petrie, Kanter, Raskind and Wilkinson. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited. |
spellingShingle | Neuroscience Radant, Allen D. Dobie, Dorcas J. Peskind, Elaine R. Murburg, M. Michele Petrie, Eric C. Kanter, Evan D. Raskind, Murray A. Wilkinson, Charles W. Adrenocortical Responsiveness to Infusions of Physiological Doses of ACTH is not Altered in Posttraumatic Stress Disorder |
title | Adrenocortical Responsiveness to Infusions of Physiological Doses of ACTH is not Altered in Posttraumatic Stress Disorder |
title_full | Adrenocortical Responsiveness to Infusions of Physiological Doses of ACTH is not Altered in Posttraumatic Stress Disorder |
title_fullStr | Adrenocortical Responsiveness to Infusions of Physiological Doses of ACTH is not Altered in Posttraumatic Stress Disorder |
title_full_unstemmed | Adrenocortical Responsiveness to Infusions of Physiological Doses of ACTH is not Altered in Posttraumatic Stress Disorder |
title_short | Adrenocortical Responsiveness to Infusions of Physiological Doses of ACTH is not Altered in Posttraumatic Stress Disorder |
title_sort | adrenocortical responsiveness to infusions of physiological doses of acth is not altered in posttraumatic stress disorder |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773172/ https://www.ncbi.nlm.nih.gov/pubmed/19893760 http://dx.doi.org/10.3389/neuro.08.040.2009 |
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