Localised and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motility

Here we use intravital imaging to demonstrate a reversible transition to a motile state as breast cancer cells spread. Imaging primary tumours reveals heterogeneity in cell morphology and motility. Two distinct modes of motility are observed: collective and single-celled. By monitoring the localisat...

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Detalles Bibliográficos
Autores principales: Giampieri, Silvia, Manning, Cerys, Hooper, Steven, Jones, Louise, Hill, Caroline S., Sahai, Erik
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773241/
https://www.ncbi.nlm.nih.gov/pubmed/19838175
http://dx.doi.org/10.1038/ncb1973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773241/
https://www.ncbi.nlm.nih.gov/pubmed/19838175
http://dx.doi.org/10.1038/ncb1973

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