Cargando…

High resolution carotid black-blood 3T MR with parallel imaging and dedicated 4-channel surface coils

BACKGROUND: Most of the carotid plaque MR studies have been performed using black-blood protocols at 1.5 T without parallel imaging techniques. The purpose of this study was to evaluate a multi-sequence, black-blood MR protocol using parallel imaging and a dedicated 4-channel surface coil for vessel...

Descripción completa

Detalles Bibliográficos
Autores principales: Saam, Tobias, Raya, Jose G, Cyran, Clemens C, Bochmann, Katja, Meimarakis, Georgios, Dietrich, Olaf, Clevert, Dirk A, Frey, Ute, Yuan, Chun, Hatsukami, Thomas S, Werf, Abe, Reiser, Maximilian F, Nikolaou, Konstantin
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773764/
https://www.ncbi.nlm.nih.gov/pubmed/19860875
http://dx.doi.org/10.1186/1532-429X-11-41
_version_ 1782173895461175296
author Saam, Tobias
Raya, Jose G
Cyran, Clemens C
Bochmann, Katja
Meimarakis, Georgios
Dietrich, Olaf
Clevert, Dirk A
Frey, Ute
Yuan, Chun
Hatsukami, Thomas S
Werf, Abe
Reiser, Maximilian F
Nikolaou, Konstantin
author_facet Saam, Tobias
Raya, Jose G
Cyran, Clemens C
Bochmann, Katja
Meimarakis, Georgios
Dietrich, Olaf
Clevert, Dirk A
Frey, Ute
Yuan, Chun
Hatsukami, Thomas S
Werf, Abe
Reiser, Maximilian F
Nikolaou, Konstantin
author_sort Saam, Tobias
collection PubMed
description BACKGROUND: Most of the carotid plaque MR studies have been performed using black-blood protocols at 1.5 T without parallel imaging techniques. The purpose of this study was to evaluate a multi-sequence, black-blood MR protocol using parallel imaging and a dedicated 4-channel surface coil for vessel wall imaging of the carotid arteries at 3 T. MATERIALS AND METHODS: 14 healthy volunteers and 14 patients with intimal thickening as proven by duplex ultrasound had their carotid arteries imaged at 3 T using a multi-sequence protocol (time-of-flight MR angiography, pre-contrast T1w-, PDw- and T2w sequences in the volunteers, additional post-contrast T1w- and dynamic contrast enhanced sequences in patients). To assess intrascan reproducibility, 10 volunteers were scanned twice within 2 weeks. RESULTS: Intrascan reproducibility for quantitative measurements of lumen, wall and outer wall areas was excellent with Intraclass Correlation Coefficients >0.98 and measurement errors of 1.5%, 4.5% and 1.9%, respectively. Patients had larger wall areas than volunteers in both common carotid and internal carotid arteries and smaller lumen areas in internal carotid arteries (p < 0.001). Positive correlations were found between wall area and cardiovascular risk factors such as age, hypertension, coronary heart disease and hypercholesterolemia (Spearman's r = 0.45-0.76, p < 0.05). No significant correlations were found between wall area and body mass index, gender, diabetes or a family history of cardiovascular disease. CONCLUSION: The findings of this study indicate that high resolution carotid black-blood 3 T MR with parallel imaging is a fast, reproducible and robust method to assess carotid atherosclerotic plaque in vivo and this method is ready to be used in clinical practice.
format Text
id pubmed-2773764
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-27737642009-11-06 High resolution carotid black-blood 3T MR with parallel imaging and dedicated 4-channel surface coils Saam, Tobias Raya, Jose G Cyran, Clemens C Bochmann, Katja Meimarakis, Georgios Dietrich, Olaf Clevert, Dirk A Frey, Ute Yuan, Chun Hatsukami, Thomas S Werf, Abe Reiser, Maximilian F Nikolaou, Konstantin J Cardiovasc Magn Reson Research BACKGROUND: Most of the carotid plaque MR studies have been performed using black-blood protocols at 1.5 T without parallel imaging techniques. The purpose of this study was to evaluate a multi-sequence, black-blood MR protocol using parallel imaging and a dedicated 4-channel surface coil for vessel wall imaging of the carotid arteries at 3 T. MATERIALS AND METHODS: 14 healthy volunteers and 14 patients with intimal thickening as proven by duplex ultrasound had their carotid arteries imaged at 3 T using a multi-sequence protocol (time-of-flight MR angiography, pre-contrast T1w-, PDw- and T2w sequences in the volunteers, additional post-contrast T1w- and dynamic contrast enhanced sequences in patients). To assess intrascan reproducibility, 10 volunteers were scanned twice within 2 weeks. RESULTS: Intrascan reproducibility for quantitative measurements of lumen, wall and outer wall areas was excellent with Intraclass Correlation Coefficients >0.98 and measurement errors of 1.5%, 4.5% and 1.9%, respectively. Patients had larger wall areas than volunteers in both common carotid and internal carotid arteries and smaller lumen areas in internal carotid arteries (p < 0.001). Positive correlations were found between wall area and cardiovascular risk factors such as age, hypertension, coronary heart disease and hypercholesterolemia (Spearman's r = 0.45-0.76, p < 0.05). No significant correlations were found between wall area and body mass index, gender, diabetes or a family history of cardiovascular disease. CONCLUSION: The findings of this study indicate that high resolution carotid black-blood 3 T MR with parallel imaging is a fast, reproducible and robust method to assess carotid atherosclerotic plaque in vivo and this method is ready to be used in clinical practice. BioMed Central 2009-10-27 /pmc/articles/PMC2773764/ /pubmed/19860875 http://dx.doi.org/10.1186/1532-429X-11-41 Text en Copyright © 2009 Saam et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Saam, Tobias
Raya, Jose G
Cyran, Clemens C
Bochmann, Katja
Meimarakis, Georgios
Dietrich, Olaf
Clevert, Dirk A
Frey, Ute
Yuan, Chun
Hatsukami, Thomas S
Werf, Abe
Reiser, Maximilian F
Nikolaou, Konstantin
High resolution carotid black-blood 3T MR with parallel imaging and dedicated 4-channel surface coils
title High resolution carotid black-blood 3T MR with parallel imaging and dedicated 4-channel surface coils
title_full High resolution carotid black-blood 3T MR with parallel imaging and dedicated 4-channel surface coils
title_fullStr High resolution carotid black-blood 3T MR with parallel imaging and dedicated 4-channel surface coils
title_full_unstemmed High resolution carotid black-blood 3T MR with parallel imaging and dedicated 4-channel surface coils
title_short High resolution carotid black-blood 3T MR with parallel imaging and dedicated 4-channel surface coils
title_sort high resolution carotid black-blood 3t mr with parallel imaging and dedicated 4-channel surface coils
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773764/
https://www.ncbi.nlm.nih.gov/pubmed/19860875
http://dx.doi.org/10.1186/1532-429X-11-41
work_keys_str_mv AT saamtobias highresolutioncarotidblackblood3tmrwithparallelimaginganddedicated4channelsurfacecoils
AT rayajoseg highresolutioncarotidblackblood3tmrwithparallelimaginganddedicated4channelsurfacecoils
AT cyranclemensc highresolutioncarotidblackblood3tmrwithparallelimaginganddedicated4channelsurfacecoils
AT bochmannkatja highresolutioncarotidblackblood3tmrwithparallelimaginganddedicated4channelsurfacecoils
AT meimarakisgeorgios highresolutioncarotidblackblood3tmrwithparallelimaginganddedicated4channelsurfacecoils
AT dietricholaf highresolutioncarotidblackblood3tmrwithparallelimaginganddedicated4channelsurfacecoils
AT clevertdirka highresolutioncarotidblackblood3tmrwithparallelimaginganddedicated4channelsurfacecoils
AT freyute highresolutioncarotidblackblood3tmrwithparallelimaginganddedicated4channelsurfacecoils
AT yuanchun highresolutioncarotidblackblood3tmrwithparallelimaginganddedicated4channelsurfacecoils
AT hatsukamithomass highresolutioncarotidblackblood3tmrwithparallelimaginganddedicated4channelsurfacecoils
AT werfabe highresolutioncarotidblackblood3tmrwithparallelimaginganddedicated4channelsurfacecoils
AT reisermaximilianf highresolutioncarotidblackblood3tmrwithparallelimaginganddedicated4channelsurfacecoils
AT nikolaoukonstantin highresolutioncarotidblackblood3tmrwithparallelimaginganddedicated4channelsurfacecoils