Evidence for a Lack of a Direct Transcriptional Suppression of the Iron Regulatory Peptide Hepcidin by Hypoxia-Inducible Factors

BACKGROUND: Hepcidin is a major regulator of iron metabolism and plays a key role in anemia of chronic disease, reducing intestinal iron uptake and release from body iron stores. Hypoxia and chemical stabilizers of the hypoxia-inducible transcription factor (HIF) have been shown to suppress hepcidin...

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Detalles Bibliográficos
Autores principales: Volke, Melanie, Gale, Daniel P., Maegdefrau, Ulrike, Schley, Gunnar, Klanke, Bernd, Bosserhoff, Anja-Katrin, Maxwell, Patrick H., Eckardt, Kai-Uwe, Warnecke, Christina
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773926/
https://www.ncbi.nlm.nih.gov/pubmed/19924283
http://dx.doi.org/10.1371/journal.pone.0007875

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