Cargando…
Selenium deficiency impairs host innate immune response and induces susceptibility to Listeria monocytogenes infection
BACKGROUND: Susceptibility or resistance to infection with Listeria monocytogenes correlates with Selenium (Se) deficiency in response to infection. RESULTS: Se-deficient mouse models of listeriosis were used to study the innate immune response during the course of L. monocytogenes infection. Blood...
Autores principales: | , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774297/ https://www.ncbi.nlm.nih.gov/pubmed/19852827 http://dx.doi.org/10.1186/1471-2172-10-55 |
_version_ | 1782173923426697216 |
---|---|
author | Wang, Chengmin Wang, Haijing Luo, Jing Hu, Yi Wei, Lei Duan, Mingxing He, Hongxuan |
author_facet | Wang, Chengmin Wang, Haijing Luo, Jing Hu, Yi Wei, Lei Duan, Mingxing He, Hongxuan |
author_sort | Wang, Chengmin |
collection | PubMed |
description | BACKGROUND: Susceptibility or resistance to infection with Listeria monocytogenes correlates with Selenium (Se) deficiency in response to infection. RESULTS: Se-deficient mouse models of listeriosis were used to study the innate immune response during the course of L. monocytogenes infection. Blood samples from mouse models were used for Se status. The concentration of MDA, SOD, GPx and CAT in blood has revealed that lower Se level exist in Se-deficient mice. Intestine, mesenteric lymph node, liver, spleen and brain from each mouse were to study the bacterial burden in organs. The analysis of cell types of spleen from Se-deficient mice revealed that the ability of the host to elicit a rapid recruitment and activation of systemic innate immune response to infection was to a certain extent compromised under conditions of Se deficiency. The cytokine levels in the serum and cytokine expression levels in the livers from Se-deficient mice revealed that the innate immune response of Se-deficient mice was impaired throughout the course of infection. These results suggest that innate immune response is altered by Se deficiency after infection with L. monocytogenes. CONCLUSION: In conclusion, induced susceptibility of host resistance is associated with an impaired innate immune response following infection with L. monocytogenes in C57BL/6 Se-deficient mice. |
format | Text |
id | pubmed-2774297 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-27742972009-11-07 Selenium deficiency impairs host innate immune response and induces susceptibility to Listeria monocytogenes infection Wang, Chengmin Wang, Haijing Luo, Jing Hu, Yi Wei, Lei Duan, Mingxing He, Hongxuan BMC Immunol Research Article BACKGROUND: Susceptibility or resistance to infection with Listeria monocytogenes correlates with Selenium (Se) deficiency in response to infection. RESULTS: Se-deficient mouse models of listeriosis were used to study the innate immune response during the course of L. monocytogenes infection. Blood samples from mouse models were used for Se status. The concentration of MDA, SOD, GPx and CAT in blood has revealed that lower Se level exist in Se-deficient mice. Intestine, mesenteric lymph node, liver, spleen and brain from each mouse were to study the bacterial burden in organs. The analysis of cell types of spleen from Se-deficient mice revealed that the ability of the host to elicit a rapid recruitment and activation of systemic innate immune response to infection was to a certain extent compromised under conditions of Se deficiency. The cytokine levels in the serum and cytokine expression levels in the livers from Se-deficient mice revealed that the innate immune response of Se-deficient mice was impaired throughout the course of infection. These results suggest that innate immune response is altered by Se deficiency after infection with L. monocytogenes. CONCLUSION: In conclusion, induced susceptibility of host resistance is associated with an impaired innate immune response following infection with L. monocytogenes in C57BL/6 Se-deficient mice. BioMed Central 2009-10-24 /pmc/articles/PMC2774297/ /pubmed/19852827 http://dx.doi.org/10.1186/1471-2172-10-55 Text en Copyright © 2009 Wang et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Wang, Chengmin Wang, Haijing Luo, Jing Hu, Yi Wei, Lei Duan, Mingxing He, Hongxuan Selenium deficiency impairs host innate immune response and induces susceptibility to Listeria monocytogenes infection |
title | Selenium deficiency impairs host innate immune response and induces susceptibility to Listeria monocytogenes infection |
title_full | Selenium deficiency impairs host innate immune response and induces susceptibility to Listeria monocytogenes infection |
title_fullStr | Selenium deficiency impairs host innate immune response and induces susceptibility to Listeria monocytogenes infection |
title_full_unstemmed | Selenium deficiency impairs host innate immune response and induces susceptibility to Listeria monocytogenes infection |
title_short | Selenium deficiency impairs host innate immune response and induces susceptibility to Listeria monocytogenes infection |
title_sort | selenium deficiency impairs host innate immune response and induces susceptibility to listeria monocytogenes infection |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774297/ https://www.ncbi.nlm.nih.gov/pubmed/19852827 http://dx.doi.org/10.1186/1471-2172-10-55 |
work_keys_str_mv | AT wangchengmin seleniumdeficiencyimpairshostinnateimmuneresponseandinducessusceptibilitytolisteriamonocytogenesinfection AT wanghaijing seleniumdeficiencyimpairshostinnateimmuneresponseandinducessusceptibilitytolisteriamonocytogenesinfection AT luojing seleniumdeficiencyimpairshostinnateimmuneresponseandinducessusceptibilitytolisteriamonocytogenesinfection AT huyi seleniumdeficiencyimpairshostinnateimmuneresponseandinducessusceptibilitytolisteriamonocytogenesinfection AT weilei seleniumdeficiencyimpairshostinnateimmuneresponseandinducessusceptibilitytolisteriamonocytogenesinfection AT duanmingxing seleniumdeficiencyimpairshostinnateimmuneresponseandinducessusceptibilitytolisteriamonocytogenesinfection AT hehongxuan seleniumdeficiencyimpairshostinnateimmuneresponseandinducessusceptibilitytolisteriamonocytogenesinfection |