In Vitro Synergy of Levofloxacin Plus Piperacillin/Tazobactam against Pseudomonas aeruginosa

In vitro synergy testing using levofloxacin (LVX) plus piperacillin/tazobactam (TZP) was performed by Etest and time-kill assay (TKA) for 31 unique fluoroquinolone-resistant Pseudomonas aeruginosa isolates. The Etest method showed synergy for 9/31 (29%) of isolates, while TKA showed synergy with 14/...

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Autores principales: Chachanidze, Vladimir, Curbelo-Irizarry, Aixa, Ashcraft, Deborah, Pankey, George
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774528/
https://www.ncbi.nlm.nih.gov/pubmed/19911066
http://dx.doi.org/10.1155/2009/984934
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author Chachanidze, Vladimir
Curbelo-Irizarry, Aixa
Ashcraft, Deborah
Pankey, George
author_facet Chachanidze, Vladimir
Curbelo-Irizarry, Aixa
Ashcraft, Deborah
Pankey, George
author_sort Chachanidze, Vladimir
collection PubMed
description In vitro synergy testing using levofloxacin (LVX) plus piperacillin/tazobactam (TZP) was performed by Etest and time-kill assay (TKA) for 31 unique fluoroquinolone-resistant Pseudomonas aeruginosa isolates. The Etest method showed synergy for 9/31 (29%) of isolates, while TKA showed synergy with 14/31 (45%) of isolates. When comparing the Etest method and TKA, concordant results for synergy, antagonism, and indifference were obtained for 24/31 (77%) of the isolates tested.
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spelling pubmed-27745282009-11-12 In Vitro Synergy of Levofloxacin Plus Piperacillin/Tazobactam against Pseudomonas aeruginosa Chachanidze, Vladimir Curbelo-Irizarry, Aixa Ashcraft, Deborah Pankey, George Interdiscip Perspect Infect Dis Research Article In vitro synergy testing using levofloxacin (LVX) plus piperacillin/tazobactam (TZP) was performed by Etest and time-kill assay (TKA) for 31 unique fluoroquinolone-resistant Pseudomonas aeruginosa isolates. The Etest method showed synergy for 9/31 (29%) of isolates, while TKA showed synergy with 14/31 (45%) of isolates. When comparing the Etest method and TKA, concordant results for synergy, antagonism, and indifference were obtained for 24/31 (77%) of the isolates tested. Hindawi Publishing Corporation 2009 2009-11-08 /pmc/articles/PMC2774528/ /pubmed/19911066 http://dx.doi.org/10.1155/2009/984934 Text en Copyright © 2009 Vladimir Chachanidze et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chachanidze, Vladimir
Curbelo-Irizarry, Aixa
Ashcraft, Deborah
Pankey, George
In Vitro Synergy of Levofloxacin Plus Piperacillin/Tazobactam against Pseudomonas aeruginosa
title In Vitro Synergy of Levofloxacin Plus Piperacillin/Tazobactam against Pseudomonas aeruginosa
title_full In Vitro Synergy of Levofloxacin Plus Piperacillin/Tazobactam against Pseudomonas aeruginosa
title_fullStr In Vitro Synergy of Levofloxacin Plus Piperacillin/Tazobactam against Pseudomonas aeruginosa
title_full_unstemmed In Vitro Synergy of Levofloxacin Plus Piperacillin/Tazobactam against Pseudomonas aeruginosa
title_short In Vitro Synergy of Levofloxacin Plus Piperacillin/Tazobactam against Pseudomonas aeruginosa
title_sort in vitro synergy of levofloxacin plus piperacillin/tazobactam against pseudomonas aeruginosa
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774528/
https://www.ncbi.nlm.nih.gov/pubmed/19911066
http://dx.doi.org/10.1155/2009/984934
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AT ashcraftdeborah invitrosynergyoflevofloxacinpluspiperacillintazobactamagainstpseudomonasaeruginosa
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