Comparison on Functional Assays for Gq-Coupled GPCRs by Measuring Inositol Monophospate-1 and Intracellular Calcium in 1536-Well Plate Format

Cell-based functional assays used for compound screening and lead optimization play an important role in drug discovery for G-protein coupled receptors (GPCRs). Cell-based assays can define the role of a compound as an agonist, antagonist or inverse agonist and can provide detailed information about...

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Detalles Bibliográficos
Autores principales: Liu, Ke, Titus, Steve, Southall, Noel, Zhu, Pingjun, Inglese, James, Austin, Christopher P, Zheng, Wei
Formato: Texto
Lenguaje:English
Publicado: Bentham Open 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774619/
https://www.ncbi.nlm.nih.gov/pubmed/20161830
http://dx.doi.org/10.2174/1875397300801010070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774619/
https://www.ncbi.nlm.nih.gov/pubmed/20161830
http://dx.doi.org/10.2174/1875397300801010070

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