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Compact Polyelectrolyte Complexes: “Saloplastic” Candidates for Biomaterials

[Image: see text] Precipitates of polyelectrolyte complexes were transformed into rugged shapes suitable for bioimplants by ultracentrifugation in the presence of high salt concentration. Salt ions dope the complex, creating a softer material with viscous fluid-like properties. Complexes that were c...

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Detalles Bibliográficos
Autores principales: Porcel, Claudine H., Schlenoff, Joseph B.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2009
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774624/
https://www.ncbi.nlm.nih.gov/pubmed/19835412
http://dx.doi.org/10.1021/bm900373c
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author Porcel, Claudine H.
Schlenoff, Joseph B.
author_facet Porcel, Claudine H.
Schlenoff, Joseph B.
author_sort Porcel, Claudine H.
collection PubMed
description [Image: see text] Precipitates of polyelectrolyte complexes were transformed into rugged shapes suitable for bioimplants by ultracentrifugation in the presence of high salt concentration. Salt ions dope the complex, creating a softer material with viscous fluid-like properties. Complexes that were compacted under the centrifugal field (CoPECs) were made from poly(diallyldimethyl ammonium), PDADMA, as polycation, and poly(styrene sulfonate), PSS, or poly(methacrylic acid), PMAA, as polyanion. Dynamic mechanical testing revealed a rubbery plateau at lower frequencies for PSS/PDADMA with moduli that decreased with increasing salt concentration, as internal ion pair cross-links were broken. CoPECs had significantly lower modulii compared to similar polyelectrolyte complexes prepared by the “multilayering” method. The difference in mechanical properties was ascribed to higher water content (located in micropores) for the former and, more importantly, to their nonstoichiometric polymer composition. The modulus of PMAA/PDADMA CoPECs, under physiological conditions, demonstrated dynamic mechanical properties that were close to those of the nucleus pulposus in an intervertebral disk.
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spelling pubmed-27746242009-11-09 Compact Polyelectrolyte Complexes: “Saloplastic” Candidates for Biomaterials Porcel, Claudine H. Schlenoff, Joseph B. Biomacromolecules [Image: see text] Precipitates of polyelectrolyte complexes were transformed into rugged shapes suitable for bioimplants by ultracentrifugation in the presence of high salt concentration. Salt ions dope the complex, creating a softer material with viscous fluid-like properties. Complexes that were compacted under the centrifugal field (CoPECs) were made from poly(diallyldimethyl ammonium), PDADMA, as polycation, and poly(styrene sulfonate), PSS, or poly(methacrylic acid), PMAA, as polyanion. Dynamic mechanical testing revealed a rubbery plateau at lower frequencies for PSS/PDADMA with moduli that decreased with increasing salt concentration, as internal ion pair cross-links were broken. CoPECs had significantly lower modulii compared to similar polyelectrolyte complexes prepared by the “multilayering” method. The difference in mechanical properties was ascribed to higher water content (located in micropores) for the former and, more importantly, to their nonstoichiometric polymer composition. The modulus of PMAA/PDADMA CoPECs, under physiological conditions, demonstrated dynamic mechanical properties that were close to those of the nucleus pulposus in an intervertebral disk. American Chemical Society 2009-10-19 2009-11-09 /pmc/articles/PMC2774624/ /pubmed/19835412 http://dx.doi.org/10.1021/bm900373c Text en Copyright © 2009 American Chemical Society http://pubs.acs.org This is an open-access article distributed under the ACS AuthorChoice Terms & Conditions. Any use of this article, must conform to the terms of that license which are available at http://pubs.acs.org.
spellingShingle Porcel, Claudine H.
Schlenoff, Joseph B.
Compact Polyelectrolyte Complexes: “Saloplastic” Candidates for Biomaterials
title Compact Polyelectrolyte Complexes: “Saloplastic” Candidates for Biomaterials
title_full Compact Polyelectrolyte Complexes: “Saloplastic” Candidates for Biomaterials
title_fullStr Compact Polyelectrolyte Complexes: “Saloplastic” Candidates for Biomaterials
title_full_unstemmed Compact Polyelectrolyte Complexes: “Saloplastic” Candidates for Biomaterials
title_short Compact Polyelectrolyte Complexes: “Saloplastic” Candidates for Biomaterials
title_sort compact polyelectrolyte complexes: “saloplastic” candidates for biomaterials
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774624/
https://www.ncbi.nlm.nih.gov/pubmed/19835412
http://dx.doi.org/10.1021/bm900373c
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