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The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules

The inflammatory response plays out over time in a reproducible and organized manner after an initiating stimulus. Here we showed that the genes activated in cultured mouse fibroblasts in response to the cytokine tumor necrosis factor (TNF) can be divided roughly into three groups, each with differe...

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Detalles Bibliográficos
Autores principales: Hao, Shengli, Baltimore, David
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775040/
https://www.ncbi.nlm.nih.gov/pubmed/19198593
http://dx.doi.org/10.1038/ni.1699
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author Hao, Shengli
Baltimore, David
author_facet Hao, Shengli
Baltimore, David
author_sort Hao, Shengli
collection PubMed
description The inflammatory response plays out over time in a reproducible and organized manner after an initiating stimulus. Here we showed that the genes activated in cultured mouse fibroblasts in response to the cytokine tumor necrosis factor (TNF) can be divided roughly into three groups, each with different induction kinetics. Whereas differential transcription is important in determining the grouping of these genes, differential mRNA stability also exerted a strong influence—in some cases overriding that of transcriptional control elements—on the temporal order of gene expression. mRNA transcripts expressed early have abundant AU-rich elements in their 3′-untranslated regions whereas those expressed later contain fewer. Thus mRNA stability and transcriptional control, two intrinsic characteristics of genes, control the kinetics of proinflammatory cytokine-induced gene expression.
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spelling pubmed-27750402009-11-10 The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules Hao, Shengli Baltimore, David Nat Immunol Article The inflammatory response plays out over time in a reproducible and organized manner after an initiating stimulus. Here we showed that the genes activated in cultured mouse fibroblasts in response to the cytokine tumor necrosis factor (TNF) can be divided roughly into three groups, each with different induction kinetics. Whereas differential transcription is important in determining the grouping of these genes, differential mRNA stability also exerted a strong influence—in some cases overriding that of transcriptional control elements—on the temporal order of gene expression. mRNA transcripts expressed early have abundant AU-rich elements in their 3′-untranslated regions whereas those expressed later contain fewer. Thus mRNA stability and transcriptional control, two intrinsic characteristics of genes, control the kinetics of proinflammatory cytokine-induced gene expression. 2009-02-08 2009-03 /pmc/articles/PMC2775040/ /pubmed/19198593 http://dx.doi.org/10.1038/ni.1699 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Hao, Shengli
Baltimore, David
The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules
title The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules
title_full The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules
title_fullStr The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules
title_full_unstemmed The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules
title_short The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules
title_sort stability of mrna influences the temporal order of the induction of genes encoding inflammatory molecules
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775040/
https://www.ncbi.nlm.nih.gov/pubmed/19198593
http://dx.doi.org/10.1038/ni.1699
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