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The Effects of Exercise-induced Fatigue on Acetylcholinesterase Expression and Activity at Rat Neuromuscular Junctions
Acetylcholinesterase is the enzyme that terminates neurotransmission by hydrolyzing the acetylcholine released by the motoneurons at the neuromuscular junctions. Although acetylcholinesterase has been studied for almost a century, the underlying relationship between exercise-induced fatigue and acet...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Japan Society of Histochemistry and Cytochemistry
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775104/ https://www.ncbi.nlm.nih.gov/pubmed/19918322 http://dx.doi.org/10.1267/ahc.09019 |
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author | Wen, Guo Hui, Wang Dan, Chen Xiao-Qiong, Wu Jian-Bin, Tong Chang-Qi, Li De-Liang, Lei Wei-Jun, Cai Zhi-Yuan, Li Xue-Gang, Luo |
author_facet | Wen, Guo Hui, Wang Dan, Chen Xiao-Qiong, Wu Jian-Bin, Tong Chang-Qi, Li De-Liang, Lei Wei-Jun, Cai Zhi-Yuan, Li Xue-Gang, Luo |
author_sort | Wen, Guo |
collection | PubMed |
description | Acetylcholinesterase is the enzyme that terminates neurotransmission by hydrolyzing the acetylcholine released by the motoneurons at the neuromuscular junctions. Although acetylcholinesterase has been studied for almost a century, the underlying relationship between exercise-induced fatigue and acetylcholinesterase activity at the synaptic cleft is not clear. The purpose of this study was to assess the effects of exercise-induced fatigue on the expression and activity of acetylcholinesterase at the neuromuscular junctions. The expression and activity of acetylcholinesterase at the gastrocnemius neuromuscular junctions was decreased transiently by exercise-induced fatigue and then gradually increased over 24 hr. The expression of acetylcholinesterase in the 24 hr recovery group returned to the level of the control (non-exercised) group, but the activity of acetylcholinesterase remained significantly lower. These data suggest that the decrease of acetylcholinesterase expression and activity may be involved in the production and/or maintenance of exercise-induced fatigue. |
format | Text |
id | pubmed-2775104 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Japan Society of Histochemistry and Cytochemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-27751042009-11-16 The Effects of Exercise-induced Fatigue on Acetylcholinesterase Expression and Activity at Rat Neuromuscular Junctions Wen, Guo Hui, Wang Dan, Chen Xiao-Qiong, Wu Jian-Bin, Tong Chang-Qi, Li De-Liang, Lei Wei-Jun, Cai Zhi-Yuan, Li Xue-Gang, Luo Acta Histochem Cytochem Regular Article Acetylcholinesterase is the enzyme that terminates neurotransmission by hydrolyzing the acetylcholine released by the motoneurons at the neuromuscular junctions. Although acetylcholinesterase has been studied for almost a century, the underlying relationship between exercise-induced fatigue and acetylcholinesterase activity at the synaptic cleft is not clear. The purpose of this study was to assess the effects of exercise-induced fatigue on the expression and activity of acetylcholinesterase at the neuromuscular junctions. The expression and activity of acetylcholinesterase at the gastrocnemius neuromuscular junctions was decreased transiently by exercise-induced fatigue and then gradually increased over 24 hr. The expression of acetylcholinesterase in the 24 hr recovery group returned to the level of the control (non-exercised) group, but the activity of acetylcholinesterase remained significantly lower. These data suggest that the decrease of acetylcholinesterase expression and activity may be involved in the production and/or maintenance of exercise-induced fatigue. Japan Society of Histochemistry and Cytochemistry 2009-10-30 2009-10-15 /pmc/articles/PMC2775104/ /pubmed/19918322 http://dx.doi.org/10.1267/ahc.09019 Text en © 2009 The Japan Society of Histochemistry and Cytochemistry This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Regular Article Wen, Guo Hui, Wang Dan, Chen Xiao-Qiong, Wu Jian-Bin, Tong Chang-Qi, Li De-Liang, Lei Wei-Jun, Cai Zhi-Yuan, Li Xue-Gang, Luo The Effects of Exercise-induced Fatigue on Acetylcholinesterase Expression and Activity at Rat Neuromuscular Junctions |
title | The Effects of Exercise-induced Fatigue on Acetylcholinesterase Expression and Activity at Rat Neuromuscular Junctions |
title_full | The Effects of Exercise-induced Fatigue on Acetylcholinesterase Expression and Activity at Rat Neuromuscular Junctions |
title_fullStr | The Effects of Exercise-induced Fatigue on Acetylcholinesterase Expression and Activity at Rat Neuromuscular Junctions |
title_full_unstemmed | The Effects of Exercise-induced Fatigue on Acetylcholinesterase Expression and Activity at Rat Neuromuscular Junctions |
title_short | The Effects of Exercise-induced Fatigue on Acetylcholinesterase Expression and Activity at Rat Neuromuscular Junctions |
title_sort | effects of exercise-induced fatigue on acetylcholinesterase expression and activity at rat neuromuscular junctions |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775104/ https://www.ncbi.nlm.nih.gov/pubmed/19918322 http://dx.doi.org/10.1267/ahc.09019 |
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