Interleukin-10: A Key Cytokine in Depression?

An increasing body of evidence implicates proinflammatory cytokines in psychiatric disorders, namely, in depression. Of notice, recent studies showed that anti-inflammatory cytokines, such as IL-10, also modulate depressive-like behavior. In this article, we propose that the anti-inflammatory cytoki...

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Detalles Bibliográficos
Autores principales: Roque, Susana, Correia-Neves, Margarida, Mesquita, Ana Raquel, Palha, Joana Almeida, Sousa, Nuno
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775686/
https://www.ncbi.nlm.nih.gov/pubmed/19936104
http://dx.doi.org/10.1155/2009/187894
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author Roque, Susana
Correia-Neves, Margarida
Mesquita, Ana Raquel
Palha, Joana Almeida
Sousa, Nuno
author_facet Roque, Susana
Correia-Neves, Margarida
Mesquita, Ana Raquel
Palha, Joana Almeida
Sousa, Nuno
author_sort Roque, Susana
collection PubMed
description An increasing body of evidence implicates proinflammatory cytokines in psychiatric disorders, namely, in depression. Of notice, recent studies showed that anti-inflammatory cytokines, such as IL-10, also modulate depressive-like behavior. In this article, we propose that the anti-inflammatory cytokine IL-10 is a putative link between two of the most widely reported phenomenon observed in depressed patients: the disruption of the hypothalamic-pituitary-adrenal axis and the imbalanced production of cytokines. If so, IL-10 might represent a novel target for antidepressant therapy.
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spelling pubmed-27756862009-11-23 Interleukin-10: A Key Cytokine in Depression? Roque, Susana Correia-Neves, Margarida Mesquita, Ana Raquel Palha, Joana Almeida Sousa, Nuno Cardiovasc Psychiatry Neurol Hypothesis An increasing body of evidence implicates proinflammatory cytokines in psychiatric disorders, namely, in depression. Of notice, recent studies showed that anti-inflammatory cytokines, such as IL-10, also modulate depressive-like behavior. In this article, we propose that the anti-inflammatory cytokine IL-10 is a putative link between two of the most widely reported phenomenon observed in depressed patients: the disruption of the hypothalamic-pituitary-adrenal axis and the imbalanced production of cytokines. If so, IL-10 might represent a novel target for antidepressant therapy. Hindawi Publishing Corporation 2009 2009-08-16 /pmc/articles/PMC2775686/ /pubmed/19936104 http://dx.doi.org/10.1155/2009/187894 Text en Copyright © 2009 Susana Roque et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Hypothesis
Roque, Susana
Correia-Neves, Margarida
Mesquita, Ana Raquel
Palha, Joana Almeida
Sousa, Nuno
Interleukin-10: A Key Cytokine in Depression?
title Interleukin-10: A Key Cytokine in Depression?
title_full Interleukin-10: A Key Cytokine in Depression?
title_fullStr Interleukin-10: A Key Cytokine in Depression?
title_full_unstemmed Interleukin-10: A Key Cytokine in Depression?
title_short Interleukin-10: A Key Cytokine in Depression?
title_sort interleukin-10: a key cytokine in depression?
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775686/
https://www.ncbi.nlm.nih.gov/pubmed/19936104
http://dx.doi.org/10.1155/2009/187894
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AT correianevesmargarida interleukin10akeycytokineindepression
AT mesquitaanaraquel interleukin10akeycytokineindepression
AT palhajoanaalmeida interleukin10akeycytokineindepression
AT sousanuno interleukin10akeycytokineindepression

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