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RNAi mediated acute depletion of Retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formation

BACKGROUND: Changes in chromosome number or structure as well as supernumerary centrosomes and multipolar mitoses are commonly observed in human tumors. Thus, centrosome amplification and mitotic checkpoint dysfunctions are believed possible causes of chromosomal instability. The Retinoblastoma tumo...

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Detalles Bibliográficos
Autores principales:	Amato, Angela, Lentini, Laura, Schillaci, Tiziana, Iovino, Flora, Di Leonardo, Aldo
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775725/ https://www.ncbi.nlm.nih.gov/pubmed/19883508 http://dx.doi.org/10.1186/1471-2121-10-79

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