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The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module

Tiam1 and Tiam2 (Tiam1/2) are guanine nucleotide-exchange factors that possess the PH–CC–Ex (pleckstrin homology, coiled coil and extra) region that mediates binding to plasma membranes and signalling proteins in the activation of Rac GTPases. Crystal structures of the PH–CC–Ex regions revealed a si...

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Detalles Bibliográficos
Autores principales:	Terawaki, Shin-ichi, Kitano, Ken, Mori, Tomoyuki, Zhai, Yan, Higuchi, Yoshiki, Itoh, Norimichi, Watanabe, Takashi, Kaibuchi, Kozo, Hakoshima, Toshio
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775898/ https://www.ncbi.nlm.nih.gov/pubmed/19893486 http://dx.doi.org/10.1038/emboj.2009.323

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