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Inhibition of PI3K-Akt Signaling Blocks Exercise-Mediated Enhancement of Adult Neurogenesis and Synaptic Plasticity in the Dentate Gyrus

BACKGROUND: Physical exercise has been shown to increase adult neurogenesis in the dentate gyrus and enhances synaptic plasticity. The antiapoptotic kinase, Akt has also been shown to be phosphorylated following voluntary exercise; however, it remains unknown whether the PI3K-Akt signaling pathway i...

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Detalles Bibliográficos
Autores principales:	Bruel-Jungerman, Elodie, Veyrac, Alexandra, Dufour, Franck, Horwood, Jennifer, Laroche, Serge, Davis, Sabrina
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775944/ https://www.ncbi.nlm.nih.gov/pubmed/19936256 http://dx.doi.org/10.1371/journal.pone.0007901

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