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Human cases of simultaneous echinococcosis and tuberculosis - significance and extent in China
During analysis of retrospective community survey data, we identified two patients from Xiji County, south Ningxia Hui Autonomous Region with simultaneous echinococcosis and tuberculosis (TB), representing the first such reports for China. As the echinococcosis chronicity increased, the immune profi...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776006/ https://www.ncbi.nlm.nih.gov/pubmed/19889226 http://dx.doi.org/10.1186/1756-3305-2-53 |
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author | Yang, Yu Rong Gray, Darren J Ellis, Magda K Yang, Shu Kun Craig, Philip S McManus, Donald P |
author_facet | Yang, Yu Rong Gray, Darren J Ellis, Magda K Yang, Shu Kun Craig, Philip S McManus, Donald P |
author_sort | Yang, Yu Rong |
collection | PubMed |
description | During analysis of retrospective community survey data, we identified two patients from Xiji County, south Ningxia Hui Autonomous Region with simultaneous echinococcosis and tuberculosis (TB), representing the first such reports for China. As the echinococcosis chronicity increased, the immune profile in both subjects changed from a Th1 to Th2 response, as shown by a TB skin test, originally positive, becoming negative. Such an elevated Th2 immune profile, with subsequent suppression of the Th1 immune response, is a common feature of chronic helminth infections. Given the difficulties in definitive diagnosis, and the potential increased susceptibility for TB infection in patients with advanced echinococcosis, we suggest that combined TB/echinococcosis surveys be undertaken in this area in the future. This would allow early diagnosis of both TB and echinococcosis cases with better prognosis for effective and sustainable treatment outcomes, ultimately reducing associated morbidity and mortality, and also the overall financial costs to the individual and the public health care system in this under developed part of China. |
format | Text |
id | pubmed-2776006 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-27760062009-11-12 Human cases of simultaneous echinococcosis and tuberculosis - significance and extent in China Yang, Yu Rong Gray, Darren J Ellis, Magda K Yang, Shu Kun Craig, Philip S McManus, Donald P Parasit Vectors Short Report During analysis of retrospective community survey data, we identified two patients from Xiji County, south Ningxia Hui Autonomous Region with simultaneous echinococcosis and tuberculosis (TB), representing the first such reports for China. As the echinococcosis chronicity increased, the immune profile in both subjects changed from a Th1 to Th2 response, as shown by a TB skin test, originally positive, becoming negative. Such an elevated Th2 immune profile, with subsequent suppression of the Th1 immune response, is a common feature of chronic helminth infections. Given the difficulties in definitive diagnosis, and the potential increased susceptibility for TB infection in patients with advanced echinococcosis, we suggest that combined TB/echinococcosis surveys be undertaken in this area in the future. This would allow early diagnosis of both TB and echinococcosis cases with better prognosis for effective and sustainable treatment outcomes, ultimately reducing associated morbidity and mortality, and also the overall financial costs to the individual and the public health care system in this under developed part of China. BioMed Central 2009-11-04 /pmc/articles/PMC2776006/ /pubmed/19889226 http://dx.doi.org/10.1186/1756-3305-2-53 Text en Copyright © 2009 Yang et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Report Yang, Yu Rong Gray, Darren J Ellis, Magda K Yang, Shu Kun Craig, Philip S McManus, Donald P Human cases of simultaneous echinococcosis and tuberculosis - significance and extent in China |
title | Human cases of simultaneous echinococcosis and tuberculosis - significance and extent in China |
title_full | Human cases of simultaneous echinococcosis and tuberculosis - significance and extent in China |
title_fullStr | Human cases of simultaneous echinococcosis and tuberculosis - significance and extent in China |
title_full_unstemmed | Human cases of simultaneous echinococcosis and tuberculosis - significance and extent in China |
title_short | Human cases of simultaneous echinococcosis and tuberculosis - significance and extent in China |
title_sort | human cases of simultaneous echinococcosis and tuberculosis - significance and extent in china |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776006/ https://www.ncbi.nlm.nih.gov/pubmed/19889226 http://dx.doi.org/10.1186/1756-3305-2-53 |
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