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Near-infrared reflectance imaging of neovascular age-related macular degeneration

PURPOSE: To evaluate various types of neovascular age-related macular degeneration (AMD) by near-infrared fundus reflectance (NIR) as compared to fundus fluorescein angiography (FFA) and to test NIR for assessment of leakage due to choroidal neovascularization (CNV). PATIENTS AND METHODS: Thirty-thr...

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Autores principales: Theelen, Thomas, Berendschot, Tos T. J. M., Hoyng, Carel B., Boon, Camiel J. F., Klevering, B. Jeroen
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776157/
https://www.ncbi.nlm.nih.gov/pubmed/19641931
http://dx.doi.org/10.1007/s00417-009-1148-9
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author Theelen, Thomas
Berendschot, Tos T. J. M.
Hoyng, Carel B.
Boon, Camiel J. F.
Klevering, B. Jeroen
author_facet Theelen, Thomas
Berendschot, Tos T. J. M.
Hoyng, Carel B.
Boon, Camiel J. F.
Klevering, B. Jeroen
author_sort Theelen, Thomas
collection PubMed
description PURPOSE: To evaluate various types of neovascular age-related macular degeneration (AMD) by near-infrared fundus reflectance (NIR) as compared to fundus fluorescein angiography (FFA) and to test NIR for assessment of leakage due to choroidal neovascularization (CNV). PATIENTS AND METHODS: Thirty-three patients with neovascular AMD (cases) and 20 age-matched patients with non-exudative AMD and healthy subjects (controls) were examined with a confocal scanning laser ophthalmoscope (Heidelberg Retina Angiograph 2). NIR images of neovascular AMD were qualitatively compared to the corresponding FFA and to age-matched controls. CNV membranes and exudation areas were manually segmented on FFA and NIR and analyzed quantitatively. RESULTS: Of all cases included, five eyes had classic CNV, six had minimal classic lesions, 15 occult CNV’s and seven eyes had retinal angiomatous proliferation (RAP). A dark halo on NIR was found in all cases and showed high correspondence to leakage on FFA (r (2) = 0.93; p < 0,0005). In classic CNV and minimal classic CNV, the classic part of the lesion on FFA revealed strong correlation to a dark core surrounded by a bright reflecting ring on NIR (r (2) = 0.88; p < 0.0005). Occult parts on FFA of minimal classic CNV and occult CNV lesions appeared as poorly demarcated, jagged areas of increased NIR. RAP was characterized by speckled NIR located at the intraretinal neovascular complex. CONCLUSIONS: NIR imaging in neovascular AMD revealed characteristic alterations depending on the type of CNV. These changes may reflect histological differences of the lesions. Leakage caused local darkening of NIR, presumably originating from increased light-scattering and absorbance by fluid accumulation and sub-cellular structure alterations.
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spelling pubmed-27761572009-11-16 Near-infrared reflectance imaging of neovascular age-related macular degeneration Theelen, Thomas Berendschot, Tos T. J. M. Hoyng, Carel B. Boon, Camiel J. F. Klevering, B. Jeroen Graefes Arch Clin Exp Ophthalmol Retinal Disorders PURPOSE: To evaluate various types of neovascular age-related macular degeneration (AMD) by near-infrared fundus reflectance (NIR) as compared to fundus fluorescein angiography (FFA) and to test NIR for assessment of leakage due to choroidal neovascularization (CNV). PATIENTS AND METHODS: Thirty-three patients with neovascular AMD (cases) and 20 age-matched patients with non-exudative AMD and healthy subjects (controls) were examined with a confocal scanning laser ophthalmoscope (Heidelberg Retina Angiograph 2). NIR images of neovascular AMD were qualitatively compared to the corresponding FFA and to age-matched controls. CNV membranes and exudation areas were manually segmented on FFA and NIR and analyzed quantitatively. RESULTS: Of all cases included, five eyes had classic CNV, six had minimal classic lesions, 15 occult CNV’s and seven eyes had retinal angiomatous proliferation (RAP). A dark halo on NIR was found in all cases and showed high correspondence to leakage on FFA (r (2) = 0.93; p < 0,0005). In classic CNV and minimal classic CNV, the classic part of the lesion on FFA revealed strong correlation to a dark core surrounded by a bright reflecting ring on NIR (r (2) = 0.88; p < 0.0005). Occult parts on FFA of minimal classic CNV and occult CNV lesions appeared as poorly demarcated, jagged areas of increased NIR. RAP was characterized by speckled NIR located at the intraretinal neovascular complex. CONCLUSIONS: NIR imaging in neovascular AMD revealed characteristic alterations depending on the type of CNV. These changes may reflect histological differences of the lesions. Leakage caused local darkening of NIR, presumably originating from increased light-scattering and absorbance by fluid accumulation and sub-cellular structure alterations. Springer-Verlag 2009-07-30 2009 /pmc/articles/PMC2776157/ /pubmed/19641931 http://dx.doi.org/10.1007/s00417-009-1148-9 Text en © The Author(s) 2009 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Retinal Disorders
Theelen, Thomas
Berendschot, Tos T. J. M.
Hoyng, Carel B.
Boon, Camiel J. F.
Klevering, B. Jeroen
Near-infrared reflectance imaging of neovascular age-related macular degeneration
title Near-infrared reflectance imaging of neovascular age-related macular degeneration
title_full Near-infrared reflectance imaging of neovascular age-related macular degeneration
title_fullStr Near-infrared reflectance imaging of neovascular age-related macular degeneration
title_full_unstemmed Near-infrared reflectance imaging of neovascular age-related macular degeneration
title_short Near-infrared reflectance imaging of neovascular age-related macular degeneration
title_sort near-infrared reflectance imaging of neovascular age-related macular degeneration
topic Retinal Disorders
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776157/
https://www.ncbi.nlm.nih.gov/pubmed/19641931
http://dx.doi.org/10.1007/s00417-009-1148-9
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