Cargando…

Is cancer risk of radiation workers larger than expected?

Occupational exposures to ionising radiation mainly occur at low-dose rates and may accumulate effective doses of up to several hundred milligray. The objective of the present study is to evaluate the evidence of cancer risks from such low-dose-rate, moderate-dose (LDRMD) exposures. Our literature s...

Descripción completa

Detalles Bibliográficos
Autores principales: Jacob, P, Rühm, W, Walsh, L, Blettner, M, Hammer, G, Zeeb, H
Formato: Texto
Lenguaje:English
Publicado: BMJ Group 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776242/
https://www.ncbi.nlm.nih.gov/pubmed/19570756
http://dx.doi.org/10.1136/oem.2008.043265
_version_ 1782174077623992320
author Jacob, P
Rühm, W
Walsh, L
Blettner, M
Hammer, G
Zeeb, H
author_facet Jacob, P
Rühm, W
Walsh, L
Blettner, M
Hammer, G
Zeeb, H
author_sort Jacob, P
collection PubMed
description Occupational exposures to ionising radiation mainly occur at low-dose rates and may accumulate effective doses of up to several hundred milligray. The objective of the present study is to evaluate the evidence of cancer risks from such low-dose-rate, moderate-dose (LDRMD) exposures. Our literature search for primary epidemiological studies on cancer incidence and mortality risks from LDRMD exposures included publications from 2002 to 2007, and an update of the UK National Registry for Radiation Workers study. For each (LDRMD) study we calculated the risk for the same types of cancer among the atomic bomb survivors with the same gender proportion and matched quantities for dose, mean age attained and mean age at exposure. A combined estimator of the ratio of the excess relative risk per dose from the LDRMD study to the corresponding value for the atomic bomb survivors was 1.21 (90% CI 0.51 to 1.90). The present analysis does not confirm that the cancer risk per dose for LDRMD exposures is lower than for the atomic bomb survivors. This result challenges the cancer risk values currently assumed for occupational exposures.
format Text
id pubmed-2776242
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher BMJ Group
record_format MEDLINE/PubMed
spelling pubmed-27762422009-11-16 Is cancer risk of radiation workers larger than expected? Jacob, P Rühm, W Walsh, L Blettner, M Hammer, G Zeeb, H Occup Environ Med Review Occupational exposures to ionising radiation mainly occur at low-dose rates and may accumulate effective doses of up to several hundred milligray. The objective of the present study is to evaluate the evidence of cancer risks from such low-dose-rate, moderate-dose (LDRMD) exposures. Our literature search for primary epidemiological studies on cancer incidence and mortality risks from LDRMD exposures included publications from 2002 to 2007, and an update of the UK National Registry for Radiation Workers study. For each (LDRMD) study we calculated the risk for the same types of cancer among the atomic bomb survivors with the same gender proportion and matched quantities for dose, mean age attained and mean age at exposure. A combined estimator of the ratio of the excess relative risk per dose from the LDRMD study to the corresponding value for the atomic bomb survivors was 1.21 (90% CI 0.51 to 1.90). The present analysis does not confirm that the cancer risk per dose for LDRMD exposures is lower than for the atomic bomb survivors. This result challenges the cancer risk values currently assumed for occupational exposures. BMJ Group 2009-12 2009-06-30 /pmc/articles/PMC2776242/ /pubmed/19570756 http://dx.doi.org/10.1136/oem.2008.043265 Text en © Jacob et al 2009 http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Jacob, P
Rühm, W
Walsh, L
Blettner, M
Hammer, G
Zeeb, H
Is cancer risk of radiation workers larger than expected?
title Is cancer risk of radiation workers larger than expected?
title_full Is cancer risk of radiation workers larger than expected?
title_fullStr Is cancer risk of radiation workers larger than expected?
title_full_unstemmed Is cancer risk of radiation workers larger than expected?
title_short Is cancer risk of radiation workers larger than expected?
title_sort is cancer risk of radiation workers larger than expected?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776242/
https://www.ncbi.nlm.nih.gov/pubmed/19570756
http://dx.doi.org/10.1136/oem.2008.043265
work_keys_str_mv AT jacobp iscancerriskofradiationworkerslargerthanexpected
AT ruhmw iscancerriskofradiationworkerslargerthanexpected
AT walshl iscancerriskofradiationworkerslargerthanexpected
AT blettnerm iscancerriskofradiationworkerslargerthanexpected
AT hammerg iscancerriskofradiationworkerslargerthanexpected
AT zeebh iscancerriskofradiationworkerslargerthanexpected