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Absence of ERRα in Female Mice Confers Resistance to Bone Loss Induced by Age or Estrogen-Deficiency
BACKGROUND: ERRα is an orphan member of the nuclear hormone receptor superfamily, which acts as a transcription factor and is involved in various metabolic processes. ERRα is also highly expressed in ossification zones during mouse development as well as in human bones and cell lines. Previous data...
Autores principales: | , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Public Library of Science
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776272/ https://www.ncbi.nlm.nih.gov/pubmed/19936213 http://dx.doi.org/10.1371/journal.pone.0007942 |
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author | Teyssier, Catherine Gallet, Marlène Rabier, Bénédicte Monfoulet, Laurent Dine, Julien Macari, Claire Espallergues, Julie Horard, Béatrice Giguère, Vincent Cohen-Solal, Martine Chassande, Olivier Vanacker, Jean-Marc |
author_facet | Teyssier, Catherine Gallet, Marlène Rabier, Bénédicte Monfoulet, Laurent Dine, Julien Macari, Claire Espallergues, Julie Horard, Béatrice Giguère, Vincent Cohen-Solal, Martine Chassande, Olivier Vanacker, Jean-Marc |
author_sort | Teyssier, Catherine |
collection | PubMed |
description | BACKGROUND: ERRα is an orphan member of the nuclear hormone receptor superfamily, which acts as a transcription factor and is involved in various metabolic processes. ERRα is also highly expressed in ossification zones during mouse development as well as in human bones and cell lines. Previous data have shown that this receptor up-modulates the expression of osteopontin, which acts as an inhibitor of bone mineralization and whose absence results in resistance to ovariectomy-induced bone loss. Altogether this suggests that ERRα may negatively regulate bone mass and could impact on bone fragility that occurs in the absence of estrogens. METHODS/PRINCIPAL FINDINGS: In this report, we have determined the in vivo effect of ERRα on bone, using knock-out mice. Relative to wild type animals, female ERRαKO bones do not age and are resistant to bone loss induced by estrogen-withdrawal. Strikingly male ERRαKO mice are indistinguishable from their wild type counterparts, both at the unchallenged or gonadectomized state. Using primary cell cultures originating from ERRαKO bone marrow, we also show that ERRα acts as an inhibitor of osteoblast differentiation. CONCLUSION/SIGNIFICANCE: Down-regulating ERRα could thus be beneficial against osteoporosis. |
format | Text |
id | pubmed-2776272 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-27762722009-11-24 Absence of ERRα in Female Mice Confers Resistance to Bone Loss Induced by Age or Estrogen-Deficiency Teyssier, Catherine Gallet, Marlène Rabier, Bénédicte Monfoulet, Laurent Dine, Julien Macari, Claire Espallergues, Julie Horard, Béatrice Giguère, Vincent Cohen-Solal, Martine Chassande, Olivier Vanacker, Jean-Marc PLoS One Research Article BACKGROUND: ERRα is an orphan member of the nuclear hormone receptor superfamily, which acts as a transcription factor and is involved in various metabolic processes. ERRα is also highly expressed in ossification zones during mouse development as well as in human bones and cell lines. Previous data have shown that this receptor up-modulates the expression of osteopontin, which acts as an inhibitor of bone mineralization and whose absence results in resistance to ovariectomy-induced bone loss. Altogether this suggests that ERRα may negatively regulate bone mass and could impact on bone fragility that occurs in the absence of estrogens. METHODS/PRINCIPAL FINDINGS: In this report, we have determined the in vivo effect of ERRα on bone, using knock-out mice. Relative to wild type animals, female ERRαKO bones do not age and are resistant to bone loss induced by estrogen-withdrawal. Strikingly male ERRαKO mice are indistinguishable from their wild type counterparts, both at the unchallenged or gonadectomized state. Using primary cell cultures originating from ERRαKO bone marrow, we also show that ERRα acts as an inhibitor of osteoblast differentiation. CONCLUSION/SIGNIFICANCE: Down-regulating ERRα could thus be beneficial against osteoporosis. Public Library of Science 2009-11-20 /pmc/articles/PMC2776272/ /pubmed/19936213 http://dx.doi.org/10.1371/journal.pone.0007942 Text en Teyssier et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Teyssier, Catherine Gallet, Marlène Rabier, Bénédicte Monfoulet, Laurent Dine, Julien Macari, Claire Espallergues, Julie Horard, Béatrice Giguère, Vincent Cohen-Solal, Martine Chassande, Olivier Vanacker, Jean-Marc Absence of ERRα in Female Mice Confers Resistance to Bone Loss Induced by Age or Estrogen-Deficiency |
title | Absence of ERRα in Female Mice Confers Resistance to Bone Loss Induced by Age or Estrogen-Deficiency |
title_full | Absence of ERRα in Female Mice Confers Resistance to Bone Loss Induced by Age or Estrogen-Deficiency |
title_fullStr | Absence of ERRα in Female Mice Confers Resistance to Bone Loss Induced by Age or Estrogen-Deficiency |
title_full_unstemmed | Absence of ERRα in Female Mice Confers Resistance to Bone Loss Induced by Age or Estrogen-Deficiency |
title_short | Absence of ERRα in Female Mice Confers Resistance to Bone Loss Induced by Age or Estrogen-Deficiency |
title_sort | absence of errα in female mice confers resistance to bone loss induced by age or estrogen-deficiency |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776272/ https://www.ncbi.nlm.nih.gov/pubmed/19936213 http://dx.doi.org/10.1371/journal.pone.0007942 |
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