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Asymmetric Deactivation of HIV-1 gp41 following Fusion Inhibitor Binding

Both equilibrium and nonequilibrium factors influence the efficacy of pharmaceutical agents that target intermediate states of biochemical reactions. We explored the intermediate state inhibition of gp41, part of the HIV-1 envelope glycoprotein complex (Env) that promotes viral entry through membran...

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Detalles Bibliográficos
Autores principales:	Kahle, Kristen M., Steger, H. Kirby, Root, Michael J.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776349/ https://www.ncbi.nlm.nih.gov/pubmed/19956769 http://dx.doi.org/10.1371/journal.ppat.1000674

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