Mutations in the Human naked cuticle Homolog NKD1 Found in Colorectal Cancer Alter Wnt/Dvl/β-Catenin Signaling

BACKGROUND: Mutation of Wnt signal antagonists Apc or Axin activates β-catenin signaling in many cancers including the majority of human colorectal adenocarcinomas. The phenotype of apc or axin mutation in the fruit fly Drosophila melanogaster is strikingly similar to that caused by mutation in the...

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Detalles Bibliográficos
Autores principales: Guo, Jianhui, Cagatay, Tolga, Zhou, Guangjin, Chan, Chih-Chiang, Blythe, Shelby, Suyama, Kaye, Zheng, Li, Pan, Kaifeng, Qian, Chiping, Hamelin, Richard, Thibodeau, Stephen N., Klein, Peter S., Wharton, Keith A., Liu, Wanguo
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776356/
https://www.ncbi.nlm.nih.gov/pubmed/19956716
http://dx.doi.org/10.1371/journal.pone.0007982

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