A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights

[Image: see text] Tanshinones are abietane-type norditerpenoid quinone natural products that are the bioactive components of the Chinese medicinal herb Salvia miltiorrhiza Bunge. The initial results from a functional genomics-based investigation of tanshinone biosynthesis, specifically the functiona...

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Autores principales: Gao, Wei, Hillwig, Matthew L., Huang, Luqi, Cui, Guanghong, Wang, Xueyong, Kong, Jianqiang, Yang, Bin, Peters, Reuben J.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2009
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776380/
https://www.ncbi.nlm.nih.gov/pubmed/19905026
http://dx.doi.org/10.1021/ol902051v
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author Gao, Wei
Hillwig, Matthew L.
Huang, Luqi
Cui, Guanghong
Wang, Xueyong
Kong, Jianqiang
Yang, Bin
Peters, Reuben J.
author_facet Gao, Wei
Hillwig, Matthew L.
Huang, Luqi
Cui, Guanghong
Wang, Xueyong
Kong, Jianqiang
Yang, Bin
Peters, Reuben J.
author_sort Gao, Wei
collection PubMed
description [Image: see text] Tanshinones are abietane-type norditerpenoid quinone natural products that are the bioactive components of the Chinese medicinal herb Salvia miltiorrhiza Bunge. The initial results from a functional genomics-based investigation of tanshinone biosynthesis, specifically the functional identification of the relevant diterpene synthases from S. miltiorrhiza, are reported. The cyclohexa-1,4-diene arrangement of the distal ring poises the resulting miltiradiene for the ensuing aromatization and hydroxylation to ferruginol suggested for tanshinone biosynthesis.
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spelling pubmed-27763802009-11-12 A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights Gao, Wei Hillwig, Matthew L. Huang, Luqi Cui, Guanghong Wang, Xueyong Kong, Jianqiang Yang, Bin Peters, Reuben J. Org Lett [Image: see text] Tanshinones are abietane-type norditerpenoid quinone natural products that are the bioactive components of the Chinese medicinal herb Salvia miltiorrhiza Bunge. The initial results from a functional genomics-based investigation of tanshinone biosynthesis, specifically the functional identification of the relevant diterpene synthases from S. miltiorrhiza, are reported. The cyclohexa-1,4-diene arrangement of the distal ring poises the resulting miltiradiene for the ensuing aromatization and hydroxylation to ferruginol suggested for tanshinone biosynthesis. American Chemical Society 2009-10-20 2009-11-19 /pmc/articles/PMC2776380/ /pubmed/19905026 http://dx.doi.org/10.1021/ol902051v Text en Copyright © 2009 American Chemical Society http://pubs.acs.org This is an open-access article distributed under the ACS AuthorChoice Terms & Conditions. Any use of this article, must conform to the terms of that license which are available at http://pubs.acs.org.
spellingShingle Gao, Wei
Hillwig, Matthew L.
Huang, Luqi
Cui, Guanghong
Wang, Xueyong
Kong, Jianqiang
Yang, Bin
Peters, Reuben J.
A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights
title A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights
title_full A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights
title_fullStr A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights
title_full_unstemmed A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights
title_short A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights
title_sort functional genomics approach to tanshinone biosynthesis provides stereochemical insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776380/
https://www.ncbi.nlm.nih.gov/pubmed/19905026
http://dx.doi.org/10.1021/ol902051v
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