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Copper-Mediated Amidation of Heterocyclic and Aromatic C−H Bonds
[Image: see text] A copper-mediated aerobic coupling reaction enables direct amidation of heterocycles or aromatics having weakly acidic C−H bonds with a variety of nitrogen nucleophiles. These reactions provide efficient access to many biologically important skeletons, including ones with the poten...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776381/ https://www.ncbi.nlm.nih.gov/pubmed/19860425 http://dx.doi.org/10.1021/ol902079g |
| _version_ | 1782174091116019712 |
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| author | Wang, Qiu Schreiber, Stuart L. |
| author_facet | Wang, Qiu Schreiber, Stuart L. |
| author_sort | Wang, Qiu |
| collection | PubMed |
| description | [Image: see text] A copper-mediated aerobic coupling reaction enables direct amidation of heterocycles or aromatics having weakly acidic C−H bonds with a variety of nitrogen nucleophiles. These reactions provide efficient access to many biologically important skeletons, including ones with the potential to serve as inhibitors of HMTs. |
| format | Text |
| id | pubmed-2776381 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2009 |
| publisher | American Chemical Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-27763812009-11-12 Copper-Mediated Amidation of Heterocyclic and Aromatic C−H Bonds Wang, Qiu Schreiber, Stuart L. Org Lett [Image: see text] A copper-mediated aerobic coupling reaction enables direct amidation of heterocycles or aromatics having weakly acidic C−H bonds with a variety of nitrogen nucleophiles. These reactions provide efficient access to many biologically important skeletons, including ones with the potential to serve as inhibitors of HMTs. American Chemical Society 2009-10-27 2009-11-19 /pmc/articles/PMC2776381/ /pubmed/19860425 http://dx.doi.org/10.1021/ol902079g Text en Copyright © 2009 American Chemical Society http://pubs.acs.org This is an open-access article distributed under the ACS AuthorChoice Terms & Conditions. Any use of this article, must conform to the terms of that license which are available at http://pubs.acs.org. |
| spellingShingle | Wang, Qiu Schreiber, Stuart L. Copper-Mediated Amidation of Heterocyclic and Aromatic C−H Bonds |
| title | Copper-Mediated Amidation of Heterocyclic and Aromatic C−H Bonds |
| title_full | Copper-Mediated Amidation of Heterocyclic and Aromatic C−H Bonds |
| title_fullStr | Copper-Mediated Amidation of Heterocyclic and Aromatic C−H Bonds |
| title_full_unstemmed | Copper-Mediated Amidation of Heterocyclic and Aromatic C−H Bonds |
| title_short | Copper-Mediated Amidation of Heterocyclic and Aromatic C−H Bonds |
| title_sort | copper-mediated amidation of heterocyclic and aromatic c−h bonds |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776381/ https://www.ncbi.nlm.nih.gov/pubmed/19860425 http://dx.doi.org/10.1021/ol902079g |
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