Bridge helix and trigger loop perturbations generate superactive RNA polymerases

BACKGROUND: Cellular RNA polymerases are highly conserved enzymes that undergo complex conformational changes to coordinate the processing of nucleic acid substrates through the active site. Two domains in particular, the bridge helix and the trigger loop, play a key role in this mechanism by adopti...

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Detalles Bibliográficos
Autores principales: Tan, Lin, Wiesler, Simone, Trzaska, Dominika, Carney, Hannah C, Weinzierl, Robert OJ
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776397/
https://www.ncbi.nlm.nih.gov/pubmed/19055851
http://dx.doi.org/10.1186/jbiol98

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776397/
https://www.ncbi.nlm.nih.gov/pubmed/19055851
http://dx.doi.org/10.1186/jbiol98

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