NFIX – one gene, two knockouts, multiple effects

A previous knockout of the transcription factor gene nuclear factor IX (NFIX) in mice produced impaired development of the corpus callosum and severe skeletal defects. A recent paper in BMC Developmental Biology reports an apparently similar NFIX knockout that produced marked differences in phenotyp...

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Detalles Bibliográficos
Autores principales: Pekarik, Vladimir, Belmonte, Juan Carlos Izpisua
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776400/
https://www.ncbi.nlm.nih.gov/pubmed/18983696
http://dx.doi.org/10.1186/jbiol94
Descripción
Sumario:A previous knockout of the transcription factor gene nuclear factor IX (NFIX) in mice produced impaired development of the corpus callosum and severe skeletal defects. A recent paper in BMC Developmental Biology reports an apparently similar NFIX knockout that produced marked differences in phenotype, raising intriguing general questions about the possible causes of such differences in mouse knockouts.

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