NFIX – one gene, two knockouts, multiple effects

A previous knockout of the transcription factor gene nuclear factor IX (NFIX) in mice produced impaired development of the corpus callosum and severe skeletal defects. A recent paper in BMC Developmental Biology reports an apparently similar NFIX knockout that produced marked differences in phenotyp...

Descripción completa

Detalles Bibliográficos
Autores principales: Pekarik, Vladimir, Belmonte, Juan Carlos Izpisua
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776400/
https://www.ncbi.nlm.nih.gov/pubmed/18983696
http://dx.doi.org/10.1186/jbiol94
_version_ 1782174095122628608
author Pekarik, Vladimir
Belmonte, Juan Carlos Izpisua
author_facet Pekarik, Vladimir
Belmonte, Juan Carlos Izpisua
author_sort Pekarik, Vladimir
collection PubMed
description A previous knockout of the transcription factor gene nuclear factor IX (NFIX) in mice produced impaired development of the corpus callosum and severe skeletal defects. A recent paper in BMC Developmental Biology reports an apparently similar NFIX knockout that produced marked differences in phenotype, raising intriguing general questions about the possible causes of such differences in mouse knockouts.
format Text
id pubmed-2776400
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-27764002009-11-13 NFIX – one gene, two knockouts, multiple effects Pekarik, Vladimir Belmonte, Juan Carlos Izpisua J Biol Minireview A previous knockout of the transcription factor gene nuclear factor IX (NFIX) in mice produced impaired development of the corpus callosum and severe skeletal defects. A recent paper in BMC Developmental Biology reports an apparently similar NFIX knockout that produced marked differences in phenotype, raising intriguing general questions about the possible causes of such differences in mouse knockouts. BioMed Central 2008 2008-10-23 /pmc/articles/PMC2776400/ /pubmed/18983696 http://dx.doi.org/10.1186/jbiol94 Text en Copyright © 2008 BioMed Central Ltd
spellingShingle Minireview
Pekarik, Vladimir
Belmonte, Juan Carlos Izpisua
NFIX – one gene, two knockouts, multiple effects
title NFIX – one gene, two knockouts, multiple effects
title_full NFIX – one gene, two knockouts, multiple effects
title_fullStr NFIX – one gene, two knockouts, multiple effects
title_full_unstemmed NFIX – one gene, two knockouts, multiple effects
title_short NFIX – one gene, two knockouts, multiple effects
title_sort nfix – one gene, two knockouts, multiple effects
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776400/
https://www.ncbi.nlm.nih.gov/pubmed/18983696
http://dx.doi.org/10.1186/jbiol94
work_keys_str_mv AT pekarikvladimir nfixonegenetwoknockoutsmultipleeffects
AT belmontejuancarlosizpisua nfixonegenetwoknockoutsmultipleeffects

Ejemplares similares